Introduction to Oncogenes and Molecular Cancer Medicine

ISBN-13: 9780387983929 / Angielski / Miękka / 1998 / 168 str.

D. W. Ross; Dennis A. Ross

Opis

Scientists now understand that cancer is a genetic disease and cutting -edge molecular therapies are making their way from the laboratory into clinical practice. Introduction to Oncogenes and Molecular Cancer Medicine provides the physician with a solid understanding of molecular biology and its applications for the diagnosis and treatment of cancer. The book reviews the basic molecular principles and the basic principles of cancer medicine, including controls of cell growth and senescence, carcinogenesis, tumorogenesis, and epidemiology. The second part of the book gives clinical examples to demonstrate the basic science principles, including chapters on leukemia, colon cancer, and breast cancer. A chapter on molecular diagnostics and screening plus a chapter on new molecular anti-cancer therapies give the reader a look at current cutting-edge therapies as well as as the future of molecular cancer medicine. A useful glossary defines new terminology at-a-glance. Introduction to Oncogenes and Molecular Cancer Medicine is for all physicians seeking a better understanding of the modern molecular principles of cancer medicine. Written in a user-friendly, conversational format, this text will be welcomed by all physicians eager to sharpen their own understanding of molecular cancer medicine as well as to help them provide patients with balanced information on the advances and limitations of current treatment options.

Spis treści

I Basic Principles of Molecular Biology.- 1 Molecular Biology of Cells.- Overview: What Is a Gene? • The Human Genome—Physical Structure • The Human Genome—Information Content • Anatomy of a Gene • Basic Genetics • Summary • References.- 2 Cell Growth and Senescence.- Overview • Cell Culture Model • Cell Cycle • DNA Synthesis DNA Repair • Checkpoints • Apoptosis • Aging—An Aside • Summary • References.- 3 Oncogenes: Control of Cell Growth and Senescence.- Overview • Analogy: The Registrar’s Mutation • Proto-Oncogene Functions • Oncogenes and Clonal Proliferation • Mutations that Convert Proto-Oncogenes to Oncogenes • Genetic Structure of Oncogenes • Summary • References.- 4 Tumor Suppressor Genes.- Overview • Genetics of Tumor Suppressor Genes and Loss of Heterozygosity (LOH) • Function of Tumor Suppressor Genes • Summary • References.- 5 Multiple Steps in the Molecular Causes of Cancer.- Overview • Carcinogenesis • Chemoprotection from Cancer • Angiogenesis • Tissue Invasion and Metastasis • Tumor Immunology • The Complexity of the Immune System—An Aside • Summary of Part I (Chapters 1–5) • References.- II Clinical Examples of Molecular Oncology.- 6 Molecular Diagnostics.- Overview • Scale of Damage to DNA • Cytometry • Chromosome Analysis • Gene Probes • Summary • References.- 7 Leukemia and Lymphoma.- Overview • Molecular Evolution of a Leukemia • Similar Molecular Events in Three Types of Lymphoma • Summary • References.- 8 Colon Cancer.- Overview • Hereditary Colon Cancer • Molecular Evolution of Colon Cancer • Carcinogenesis and Colon Cancer • Screening and Early Detection • Molecular Staging • Molecular Therapies • Summary • References.- 9 Squamous Cell Carcinoma of the Uterine Cervix.- Overview • Cytologic Progression of Cervical Cancer • Molecular Biology of Human Papilloma Virus (HPV) and Cervical Cancer • Summary • References.- 10 Breast Cancer.- Overview • Molecular Pathology • Staging and Multiple Prognostic Factors • Breast Cancer “Field Effect”—A Special Problem • Breast Cancer Susceptibility Genes • Summary • References.- 11 Molecular Anticancer Therapies.- Overview • Molecular Targets in Cancer • Antisense Oligonucleotides • Immune Mediated Therapy • Infectious Vaccines—An Aside • Genetic Engineering • Summary • References •.- Conclusions.