Transport Processes in Pharmaceutical Systems

ISBN-13: 9780367399221 / Angielski / Miękka / 2019 / 748 str.

Gordon L. Amidon; Ping I. Lee; Elizabeth M. Topp

Opis

This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity.
Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems.
Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems

discusses the crucial relationship between the transport process and thermodynamic factors

analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces

covers prodrug design for improving membrane transport

addresses the effects of external stimuli in altering some natural and synthetic polymer matrices

examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability

presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions

and more!
Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.

Spis treści

Introduction to Transport Processes

Principles of Mass Transfer
Elizabeth M. Topp
Analytical Solutions to Mass Transfer
Lawrence X. Yu and Gordon L. Amidon
Pharmacokinetics: Model Structure and Transport Systems
James M. Gallo
Experimental Methods to Evaluate Diffusion Coefficients and Investigate Transport Processes of Pharmaceutical Interest
John W. Mauger
Dissolution of Pharmaceuticals in Simple and Complex Systems
Daniel P. McNamara, Michael L. Vieira, and John R. Crison

Biological Transport Processes

Biological Transport Phenomena in the Gastrointestinal Tract: Cellular Mechanisms
David Fleisher
Improving Oral Drug Transport via Prodrugs
Mandana Asgharnejad
Quantitative Approaches to Delineate Passive Transport Mechanisms in Cell Culture Monolayers
Norman F. H. Ho, Thomas J. Raub, Phillip S. Burton, Craig L. Barsuhn, Anthony Adson, Kenneth L. Audus, and Ronald T. Borchardt
Barriers to Drug Transport in Ocular Epithelia
Uday B. Kompella and Vincent H. L. Lee
Predicting Oral Drug Absorption in Humans
Lawrence Yu, Larry Gatlin, and Gordon L. Amidon

Transport Processes in Polymer Systems

Controlled Release Osmotic Drug Delivery Systems for Oral Applications
John R. Cardinal
Transport in Polymer Systems
Jim H. Kou
Synthesis and Properties of Hydrogels Used for Drug Delivery
Stevin H. Gehrke
Stimuli-Modulated Delivery Systems
Sung Wan Kim and You Han Bae
Properties of Solids that Affect Transport
Manesh J. Nerurkar, Sarma Duddu, David J. W. Grant, and J. Howard Rytting

Heat and Mass Transport

Heat and Mass Transfer in Low Pressure Gases: Applications to Freeze Drying
Michael J. Pikal
Heat and Mass Transport: Hygroscopicity
James Wright

O autorze

Gordon L. Amidon, Ping I. Lee, Elizabeth M. Topp