The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics

ISBN-13: 9780128191828 / Angielski / Miękka / 2020

Joao Luciano de Quevedo; Andre Ferrer Carvalho; Eduard Vieta

Spis treści

1. Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC) 2. The neurodevelopmental basis of Bipolar Disorder: Mechanisms and Implications 3. The neuroprogressive nature of Bipolar Disorder: Mechanisms and Implications 4. Immune mechanisms in Bipolar Disorder: evidence and implications 5. Mitochondrial pathways in Bipolar Disorder: mechanisms and implications 6. Neuro-oxidative and neuro-nitrosative mechanisms in bipolar disorder: evidence and implications 7. Mechanisms underpinning neurocognitive dysfunction in bipolar disorder 8. The evolution of animal models for bipolar disorder 9. Alteration in Circadian rhythms in bipolar disorder: mechanisms and implications 10. The genetics of bipolar disorder 11. Pharmacogenomics of bipolar disorder 12. Blood-brain barrier dysfunction as a pathophysiological mechanism of bipolar disorder 13. Induced Pluripotent stem cells as tools for the investigation of the neurobiology of bipolar disorder 14. Bipolar disorder as a gliopathy 15. Molecular Imaging findings in Bipolar disorder 16. Structural and functional neuroimaging findings in bipolar disorder 17. Epigenetic mechanisms of bipolar disorder 18. Bipolar disorder and cardiovascular dysfunction: mechanisms and implications 19. At-risk mental states for bipolar disorder 20. Stress, allostatic load and bipolar disorder: mechanisms and implications 21. Bipolar disorder, obesity and metabolic disturbances: mechanisms and implications 22. The gut-brain axis in bipolar disorder 23. The hypothalamic-pituitary-adrenal axis in bipolar disorder 24. Disturbed neuroplasticity pathways in bipolar disorder: mechanisms and implications 25. Aberrations in intracellular signaling pathways in bipolar disorder 26. The impact of early-life stress in the development and course of bipolar disorder: mechanisms and implications 27. Bipolar disorder and accelerated aging: mechanisms and implications 28. Suicidal behaviors in bipolar disorder 29. Pediatric bipolar disorder 30. Late-life bipolar disorder 31. Biomarkers for Bipolar Disorder 32. The mechanisms of action of lithium in bipolar disorder 33. Is there a biosignature for lithium response in bipolar disorder? Evidence and implications 34. Exercise as a treatment for bipolar disorder 35. Non-invasive neuromodulatory approaches for bipolar disorder 36. Novel therapeutic drug targets for bipolar disorder 37. The treatment of bipolar disorder in the era of precision psychiatry: challenges and opportunities