Multiple Sclerosis: A Mechanistic View

ISBN-13: 9780128007631 / Angielski / Twarda / 2015 / 538 str.

Minagar, Alireza

Opis

Multiple Sclerosis: A Mechanistic View provides a unique view of the pathophysiology of multiple sclerosis (MS) and related disorders. As the only book on the market to focus on the mechanisms of MS rather than focusing on the clinical features and treatment of the disease, it describes the role of genetic and environmental factors in the pathogenesis of MS, the role of specific cells in the pathophysiology of the disease, and the pathophysiology of inflammatory and neurodegenerative disorders related to MS. The book provides discussion of neurodegeneration and neuroregeneration, two critical emerging areas of research, as well as detailed discussion of the mechanisms of action of the approved and investigational drugs for treatment of MS and the emerging role of magnetic resonance spectroscopy (MRI) in investigations into MS. It is the only book on the market to offer comprehensive coverage of the known mechanisms of MS and related diseases, and contains contributions from physicians and researchers who are worldwide experts in the field of study.

• Focuses on the pathophysiologic mechanisms of multiple sclerosis and the mechanisms of action in agents for the treatment of MS
• Discusses the roles of neurodegeneration and neuroregeneration in MS and related diseases
• Authored and edited by international leaders in the field of MS research

Spis treści

1. Clinical manifestations of multiple sclerosis: An overview
2. Novel Therapies for Multiple Sclerosis: A Mechanistic View
3. Role of B cells in the pathogenesis of MS: Mechanisms of action
4. Role of CD4+ T cells in the pathophysiology of MS
5. GM-CSF in Central Nervous System Autoimmunity
6. Role of cytokine-mediated crosstalk between T cells and non-immune cells in the pathophysiology of multiple sclerosis
7. Vitamin D: role in pathogenesis of Multiple Sclerosis
8. Role of genetic factors in pathogenesis of MS
9. Neuropathology of multiple sclerosis
10. Pathophysiology of acute disseminated encephalomyelitis
11. Pathophysiology of experimental autoimmune encephalomyelitis
12. Pathophysiology of optic neuritis
13. Neurodegeneration and Remyelination in Multiple Sclerosis
14. Mechanisms of action of Glatiramer Acetate in the treatment of multiple sclerosis
15. Mechanism of Action of Interferon Beta in Treatment of Multiple Sclerosis
16. Mechanisms of blood brain barrier disintegration in the pathophysiology of MS
17. Mechanisms and potentials of Stem Cells in the treatment of Multiple Sclerosis: The unpaved path
18. Role of neuroimaging in MS
19. Pathophysiology of Lymphatic Drainage of the Central Nervous System. Implications for the Pathophysiology of Multiple Sclerosis
    

O autorze

Dr. Minagar is a Professor of Neurology at LSU Health Sciences Center in Shreveport, Louisiana. He's a certified Physician Investigator by Association of Clinical Research Professionals, member of the editorial board of Future Neurology, Neurological Research, and Alzheimer's Disease Research Board. Dr. Minagar is the author of 231 journal articles and 33 book chapters, and editor of 10 books.