3D Printing: Emerging Technologies and Functionality of Polymeric Excipients in Drug Product Development

ISBN-13: 9783031460142 / Angielski

Michael A. Repka; Nigel Langley

Spis treści

Chapter 1

“Overview of Pharmaceutical 3D Printing Technologies”

 Mike Repka / Nigel Langley

Chapter 2

“Clinical benefit of 3D printed Products”

·        Clinical Applicability of 3D printing technologies

·        3D printed Implants

Merck

Derrick Smith / Joseph De La Rocca

Chapter 3

Characterization or Quality Control of 3D printed Products

Regulatory landscape

Mansoor Khan

Chapter 4

“Polymers, for HME based 3 D printing”

·        Kollicoat IR; Kollidon SR; Kollidon VA 64: Soluplus etc

·        Functionality, properties

BASF

Jiantao Zhang

 Chapter 5

“Cellulosic Polymers”

·        HPC

·        HPMC

·        HPMCAS

·        Ethyl Cellulose etc

·        Functionality, properties

 Ashland

Tom Durig

Chapter 6

“API and Polymer Selection Formulation and Process Variables”

·        Melt Viscosity

·        Role of Plasticizers

·        Stability of API and Polymers       

St John’s University

Abu Serajuddin

Chapter 7

“Fused Deposition Modeling 3D Printing”

·        Advantages and Disadvantages of FDM 3D printing

·        3D printing Equipment

·        Production of Filaments and Case Studies

 ·        ‘Melt extrusion deposition (MED) technology’

Suresh Bandari & Mike Repka

 Xiaoling Li - University of the Pacific

Chapter 8

“Semisolid Extrusion Printing and 3D Bioprinting”

Fixed Dose Combination 3D Printing
• 3D Bio printing Approaches 

Mohammed Maniruzzman

Chapter 9

“Manufacturing Technologies and Drug development”

·        ‘Zip Dose Technology’ - Spritam® first FDA approved product

·        Personalized medicine – 3D printing in hospitals

Aprecia Pharmaceuticals

Simon Gaisford & Alvaro Goyanes- FabRx

Chapter 10

·        “Future trends including novel polymeric excipients ‘designed for purpose”

Mohammed Maniruzzman & Suresh Bandari

O autorze

Dr. Michael A. Repka is Distinguished Professor of the Department of Pharmaceutics at The University of Mississippi. He is also Founder and Director of the Pii Center for Pharmaceutical Technology. His research interests include the solubilization and delivery of poorly soluble bioactives via Hot Melt Extrusion (HME) technology, while coupling HME techniques with 3D printing to produce patient centric delivery systems . Dr. Repka has established himself as an expert in this major pharmaceutical processing field through his numerous peer-reviewed publications, presentations and scientific talks.

Dr. Nigel Langley is currently the Global Technical Director, Life Sciences at Gaylord Chemical LLC. He has a strong interest in excipient innovation, solubilization, hot melt extrusion and 3D printing.  Dr. Langley has also worked at BASF and Croda International PLC and is the current Chair of IPEC-Americas. 

Blurb

This book is an educational text and guide for the use and properties of key polymeric excipients in the area of 3D printing in drug development. It is written by both industry experts and academic researchers.  The particular focus is on hot melt extrusion and the extruded filaments suitable for optimizing the 3D printing in drug development. 3D Printing Polymeric Excipients, Technology, and Drug Formulation Development covers regulatory aspects as well as the manufacturing aspects.