25 Years of p53 Research

ISBN-13: 9781402065644 / Angielski / Miękka / 2007 / 446 str.

Klas G. Wiman; Pierre Hainaut

Opis

1. Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. Review arcticles, despite their fundamental role in disseminating knowledge, usually focus only on general mechanisms and do not discuss in detail the many variations that can occur with respect to cell type, particular mutation type, as well as biological activation context. Books such as this one may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.

Spis treści

Chapter 1: The First Twenty-Five Years of p53 Research; Harlan Robins, Gabriela Alexe, Sandra Harris and A.J. Levine Chapter 2: Regulation of p53 DNA Binding; Kristine McKinney and Carol Prives Chapter 3: 20 Years of DNA Damage Signaling to p53; Kevin G. McLure and Michael B. Kastan Chapter 4: Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX; Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel and Mark Wade Chapter 5: Regulation of the p53 Response by Cellular Growth and Survival Factors; Lauren Brown and Samuel Benchimol Chapter 6: p53, Cell Cycle Arrest and Apoptosis; Shulin Wang and Wafik S. El-Deiry Chapter 7: p53 Has a Direct Pro-apoptotic Action at the Mitochondria; Ute M. Moll Chapter 8: Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor; Lawrence A. Donehower, Dora Bocangel, Melissa Dumble and Guillermina Lozano Chapter 9: p53, p63, and p73: Internecine Relations? Frank McKeon and Annie Yang Chapter 10: p73, p63 and Mutant p53: Members of Protein Complexs Floating in Cancer Cells; Olimpia Monti, Alexander Damalas, Sabrina Strano and Giovanni Blandino Chapter 11: p53: Gatekeeper, Caretaker or Both? Carlos P. Rubbi and Jo Milner Chapter 12: Analysis of p53 Gene Alterations in Cancer: A Critical View; Thierry Soussi Chapter 13: Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection; Hong Shi, Florence Le Calvez, Magali Olivier and Pierre Hainaut Chapter 14: Prognostic and Predictive Value of TP53 Mutations in Human Cancer; Magali Olivier, Pierre Hainaut and Anne-Lise Børresen-Dale Chapter 15: p53 Links Tumor Development to Cancer Therapy; Michael T. Hemann and Scott W. Lowe Chapter 16:Novel p53-Based Therapies: Strategies and Future Prospects; Sonia Lain and David Lane Chapter 17: Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue; Andreas C. Joerger, Assaf Friedler and Alan R. Fersht Chapter 18: Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy; Galina Selivanova, Vladimir J.N. Bykov and Klas G. Wiman Chapter 19: Novel Approaches to p53-Based Therapy: ONYX-015; Frank McCormick Chapter 20: p53 as Seen by an Outsider; George Klein