It is now 10 years since the first AIDS cases were reported in the USA. In that relatively short period of time, study of the disease has moved from the level of early clinical description to exhaustive and extensive laboratory characterization of the human immunodeficiency virus (HIV), the immune responses directed towards it and reasons for their failure. This volume provides contributions from clinical and basic scientists who are actively involved in research in a number of areas of current interest and controversy. Further progress in the clinical management of the HIV-infected patient...
It is now 10 years since the first AIDS cases were reported in the USA. In that relatively short period of time, study of the disease has moved from t...
Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated. The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself. This book is essential reading for the busy physician or pathologist who wants to be up-to-date...
Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification ...
Recent developments in the field of cellular pathology and molecular biology have had a major impact on our ability to diagnose lymphoreticular disease and on our understanding of many of the disease processes which contribute to lymphoreticular pathology. Twenty years ago, the immunological analysis of lymphoid proliferations was in its infancy. The techniques available, such as sheep red blood cell rosetting and immune adherence to frozen sections, now appear unbelievably crude when compared with our ability to accurately phenotype lymphocytes in suspension, in frozen section and, more...
Recent developments in the field of cellular pathology and molecular biology have had a major impact on our ability to diagnose lymphoreticular diseas...
It has been said that "never in the history of human progress has a better and cheaper method of preventing illness been developed than immunization". This is well illustrated by the WHO Expanded Programme on Immunization (EPI) which in developing countries is now preventing nearly a million deaths annually from measles, pertussis and neonatal tetanus, and for which there is a commitment by the WHO and UNICEF to protect all children by immunization by the end of the decade. This enormous undertaking will be facilitated by the rapid advances in molecular biology and recombinant DNA technology,...
It has been said that "never in the history of human progress has a better and cheaper method of preventing illness been developed than immunization"....
The purpose of this book is to describe the nature of the materno-fetal immunobiological relationship and to suggest the direction in which the management of reproduction and its failure in man is moving. The several authors, who have written about their special fields of interest, need to be read within a framework designed to blend their contributions into a whole. This preamble provides a part of that framework, by describing the early development of the embryo, that of the placenta and its membranes and their anatomical relationship with maternal tissues: in other words, the stage upon...
The purpose of this book is to describe the nature of the materno-fetal immunobiological relationship and to suggest the direction in which the manage...
9. Wright, D. J. M. (1980). Reaction following treatment of murine borreliosis and Shwartzman type reaction with borrelial sonicates. Parasite Immunol. , 2, 201-21 10. Tekli. l, B. , Habte-Michal, A. , White, N. J. , Warrell, D. A. and Wright, D. J. M. (1983). Meptazinol diminishes the Jarisch-Herxheimer reaction. Lancet, 1, 835-9 II. Wright, D. J. M. (1973). The significance of the fluorescent treponemal antibody (FTA- ABS) test in collagen disorders and leprosy. J. Clin. Pathol. , 26, 968-72 12. Noguchi, H. (1911). A cutaneous reaction in syphilis. J. Exp. Med. , 14, 557-68 13. Frei W....
9. Wright, D. J. M. (1980). Reaction following treatment of murine borreliosis and Shwartzman type reaction with borrelial sonicates. Parasite Immunol...
The AIDS epidemic has popularized immune deficiency and has led to a rapid increase in the funding for research into the effect of viruses on immunity. There is now a real possibility of finding out whether some of the rare, so-called 'primary' immunodeficiency syndromes of children and adults, first described in the 1950s, may have a viral aetiology. Most of these syndromes have already been extensively reviewed more than once over the past 10 years, and their diagnosis and management is now included in most standard medical textbooks. In this volume, I have chosen to highlight what I...
The AIDS epidemic has popularized immune deficiency and has led to a rapid increase in the funding for research into the effect of viruses on immunity...
In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain- ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta- chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal...
In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain- ing many granules which, when stained with basic dyes, such as tolu...
Immunotherapy began in 1774 when the Dorset farmer Benjamin Jesty inoculated his wife and two sons with the pus from the teat of a cow suffering from cow pox, using his wife's knitting needle as a vaccinating implement. It has made slow progress. Meanwhile the science of Immunology has burgeoned so much that if all immunologists read every page of the Journal of Immunology, let alone the other Immunology journals, then they would have no time left to write for it. I am pleased that some of them have found the time to write for this volume. In spite of the rapid expansion in immuno logical...
Immunotherapy began in 1774 when the Dorset farmer Benjamin Jesty inoculated his wife and two sons with the pus from the teat of a cow suffering from ...