Kategoria BISAC: Science >> Chemistry - Toxicology

Interest in the field of microbial toxins is ever growing and spreading across a broad spectrum of scientific disciplines. In an effort to supplement the available reference texts on toxins, Microbial Toxins: Methods and Protocols includes protocols on mold fungus toxins, with some focus on aflatoxins. Intended to support a wide variety of researchers, Microbial Toxins: Methods and Protocols presents the reader with biological, chemical, physical, and medical approaches, as well as state-of-the-art research techniques. Divided into three convenient sections, this...

Did you know that ""nontoxic"" usually means ""never tested""? Or that many green cleaners are good for the environment but terrible for you? Chemist and activist Monona Rossol goes from under your sink to the halls of the powerful, tracing America's love affair with chemicals that kill, explaining how much worse the problem has gotten in the last decade. Shocking and appalling and completely reckless--that's how she describes the current prevalence of harmful chemicals in our...

Part one provides examples of recent outbreak investigations from a wide range of experts around the world, including lessons learnt, before part two goes on to explore examples of how the source was traced and the implications for the food chain. Methods of crisis...

Elizabeth Grossman, an acclaimed journalist who brought national attention to the contaminants hidden in computers and other high tech electronics, now tackles the hazards of ordinary consumer products. She shows that for the sake of convenience, efficiency, and short-term safety, we have...

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward.

The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro...

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency.

- Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attrition
- Tackles a problem that adds billions of dollars to drug development programs and health care costs
- Guides discovery and development scientists through R&D stages, teaching requirements and reasons why drugs can...

The Comprehensive Sourcebook of Bacterial Protein Toxins 4^th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human...

Case Studies in Nanotoxicology and Particle Toxicology presents a highly-illustrated analysis of the most prominent cases on the adverse effects of nanoparticles and their impact on humans and the environment.

This comprehensive reference demonstrates the possible risks imposed by managing and handling nanoparticles, showing the effects of involuntary inhalation or ingestion during their use and after their incineration.

Through the use of numerous examples, readers will discover the possible risks and effects of working with nanoparticles, along with best practices...

• Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations
• Provides...

Reviews of Environmental Contamination and Toxicology provides concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Antisense-based drugs are part of a growing number of pharmaceutical and biotech programs to treat diseases including cancer, diabetes, and ALS. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide from the safety assessment to clinical experience with antisense oligonucleotides.

- Examines principles and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides
- Reviews fundamentals and provides guidelines for scientists in drug design and discovery to...