Genomics of Pattern Recognition Receptors: Applications in Oncology and Cardiovascular Diseases
ISBN: 9783034806879 / Angielski / Twarda / 185 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description ...
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583,65 zł |
Transposable Elements and Genome Evolution
ISBN: 9789401058124 / Angielski / Miękka / 299 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Once considered merely selfish' or parasitic' DNA, transposable elements are today recognized as being of major biological significance. Not only are these elements a major source of mutation, they have contributed both directly and indirectly to the evolution of genome structure and function.
On October 8-10, 1999, 100 molecular biologists and evolutionists representing 11 countries met on the campus of The University of Georgia in Athens for the inaugural Georgia Genetics Symposium. The topics of presentations ranged from how the elements themselves have evolved to the impact... Once considered merely selfish' or parasitic' DNA, transposable elements are today recognized as being of major biological significance. Not only are ...
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583,65 zł |
Reproductive Toxicology: In Vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand
ISBN: 9781489900913 / Angielski / Miękka / 223 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.
Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different ...
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583,65 zł |
Technologies for Detection of DNA Damage and Mutations
ISBN: 9781489903037 / Angielski / Miękka / 441 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto- oncogenes and tumor suppressor genes may be...
Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant thr...
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583,65 zł |
Microrna in Development and in the Progression of Cancer
ISBN: 9781489980649 / Angielski / Twarda / 407 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. miRNAs are a class of endogenous, small non-protein coding RNA molecules ( 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the... miRNAs are a class of endogenous, small non-protein coding RNA molecules ( 22 nucleotides) which are novel post-transcriptional regulators of gene ... |
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583,65 zł |
Handbook of Genetics: Volume 1 Bacteria, Bacteriophages, and Fungi
ISBN: 9781489917126 / Angielski / Miękka / 676 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The purpose of this and future volumes of the Handbook of Genetics is to bring together a collection of relatively short, authoritative essays or annotated compilations of data on topics of significance to geneticists. Many of the essays will deal with various aspects of the biology of certain species selected because they are favorite subjects for genetic investigation in nature or the laboratory. Often there will be an encyclopedic amount of information available on such a species, with new papers appearing daily. Most of these will be written for specialists in a jargon that is be-...
The purpose of this and future volumes of the Handbook of Genetics is to bring together a collection of relatively short, authoritative essays or anno...
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583,65 zł |
G Protein-Coupled Receptors - Modeling and Simulation
ISBN: 9789400774223 / Angielski / Twarda / 228 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about...
G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ul...
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583,65 zł |
Advances in Human Genetics
ISBN: 9781475790641 / Angielski / Miękka / 264 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. From reviews of previous volumes in the series: 'Extremely valuable...thoroughly recommended.'-Annals of Human Genetics 'The most lucid and stimulating discussions of the topic to be found anywhere.'-American Scientist
From reviews of previous volumes in the series: 'Extremely valuable...thoroughly recommended.'-Annals of Human Genetics '...
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583,65 zł |
Genomes of Plants and Animals: 21st Stadler Genetics Symposium
ISBN: 9781489902825 / Angielski / Miękka / 320 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume brings together the disciplines of plant and animal genome research, and serves as an opportunity for scientists from both fields to compare results, problems and prospects.
This volume brings together the disciplines of plant and animal genome research, and serves as an opportunity for scientists from both fields to com...
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583,65 zł |
Gene Network Inference: Verification of Methods for Systems Genetics Data
ISBN: 9783642451607 / Angielski / Twarda / 130 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the... This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the... |
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583,65 zł |
Signaling Pathways and Molecular Mediators in Metastasis
ISBN: 9789401782586 / Angielski / Miękka / 378 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a...
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pa...
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583,65 zł |
Ethical Challenges in Genomics Research: A Guide to Understanding Ethics in Context
ISBN: 9783642427190 / Angielski / Miękka / 234 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. New developments in science and technology have resulted in shifting ethical challenges in many areas including in genomics research. This book enables those who are involved in genomics research, whether as researcher, participant or policy maker, to understand the ethical issues currently developing in this field and to participate actively in these important debates. A clear account is given of how science and technology are outstripping the capacity of previous ethical regulations to cope with current issues, together with practical illustrations of possible ways forward. Key ethical... New developments in science and technology have resulted in shifting ethical challenges in many areas including in genomics research. This book ena... |
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583,65 zł |
Phosphoinositides I: Enzymes of Synthesis and Degradation
ISBN: 9789401781572 / Angielski / Miękka / 356 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid...
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turnin...
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583,65 zł |
Microarrays in Diagnostics and Biomarker Development: Current and Future Applications
ISBN: 9783642439766 / Angielski / Miękka / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards "nanoarrays," which is expected to have great...
Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic a...
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583,65 zł |
Tissue Morphogenesis: Methods and Protocols
ISBN: 9781493911639 / Angielski / Twarda / 351 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Tissue Morphogenesis: Methods and Protocols highlights major techniques, both experimental and computational, for the study of tissue morphogenesis, divided into several sections, with specific focus on techniques to image, manipulate, model and analyze tissue morphogenesis. Chapters focus on imagining analysis of tissue morphogenesis, culture models of tissue morphogenesis, manipulating cells and tissues in vivo, novel model systems to investigate issue morphogenesis and computational models. Written in the highly successful Methods in Molecular Biology series format,... Tissue Morphogenesis: Methods and Protocols highlights major techniques, both experimental and computational, for the study of tissue morpho... |
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583,65 zł |
Regulatory Nascent Polypeptides
ISBN: 9784431550518 / Angielski / Twarda / 315 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few... This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems... |
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583,65 zł |
The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation
ISBN: 9783319015736 / Angielski / Twarda / 576 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological...
This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical applicat...
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583,65 zł |
Advances in Human Genetics
ISBN: 9781475706222 / Angielski / Miękka / 485 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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583,65 zł |
Evolutionary Genetics of Invertebrate Behavior: Progress and Prospects
ISBN: 9781489934895 / Angielski / Miękka / 336 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the preface to Sir Vincent B. Wigglesworth's classic 1939 book on insect physiology he asserted that insects provide an ideal medium in which to study all the problems of physiology. A strong case can be made as well for the use of insects as significant systems for the study of behavior and genetics. Contributions to genetics through decades of research on Drosophila species have made this small fly the most important metazoan in genetics research. At the same time, population and behavioral research on insects and other invertebrates have provid- ed new perspectives that can be combined...
In the preface to Sir Vincent B. Wigglesworth's classic 1939 book on insect physiology he asserted that insects provide an ideal medium in which to st...
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cena:
583,65 zł |
Gene Targeting Protocols
ISBN: 9781489941589 / Angielski / Miękka / 233 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situation, the cloned gene is returned to its homologous location in the genome and becomes inserted at the target locus. This process is a controlled means for the repair of DNA damage and ensures accurate chromosome disjunction during meiosis. The paradigm for thinking about the mechanism of this p- cess has emerged primarily from two sources: (1) The principles of reaction mechanics have come from detailed biochemical analyses of the RecA protein...
The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situ...
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cena:
583,65 zł |