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Protein Pharmacokinetics and Metabolism
ISBN: 9780306441516 / Angielski / Twarda / 276 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents. In addition, the development and improvement of analytical techniques enabling the detection of minute quantities of proteins in biological matrices have aided this process. In assembling this volume, we sought to provide a state-of-the-art as sessment of the pharmacokinetics and metabolism of protein therapeutics through complete reviews of selected examples. A comprehensive review of all protein therapeutics...
Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human...
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605,23 zł |
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Stability of Protein Pharmaceuticals: Part B: In Vivo Pathways of Degradation and Strategies for Protein Stabilization
ISBN: 9780306441530 / Angielski / Twarda / 328 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, details protein use in organisms, and reviews techniques to enhance protein stability.
Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, ...
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806,99 zł |
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Stability and Characterization of Protein and Peptide Drugs: Case Histories
ISBN: 9780306443657 / Angielski / Twarda / 353 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar keted or are under clinical testing. In previous volumes of this series, funda mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is...
This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar ...
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806,99 zł |
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Methods in Pharmacology: Molecular and Cellular Biology of Pharmacological Targets
ISBN: 9780306444241 / Angielski / Twarda / 278 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this volume of Methods in Pharmacology we have brought together experts in the field of ion channels to provide the reader with an in-depth view of current biochemical and electrophysiological methods. The focus is on cation-selective ion channels (voltage controlled Of ligand controlled) that are of special pharmacological interest. The con tents are divided into three sections that exemplify {I) molecular and biochemical characterization of ion channels, (II) functional analysis of ion channels (after recon stitution or expression, or in cells), and (III) specific methods and tools. The...
In this volume of Methods in Pharmacology we have brought together experts in the field of ion channels to provide the reader with an in-depth view of...
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605,23 zł |
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Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites
ISBN: 9780306446030 / Angielski / Twarda / 236 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.
In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology o...
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605,23 zł |
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Dealing with Medical Knowledge: Computers in Clinical Decision Making
ISBN: 9780306448492 / Angielski / Twarda / 298 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In a systematic and clear manner, the authors discuss the problems associated with clinical decision making and explore the current methods to solve them. In this monograph, they examine the results of combining the classical control system approach with the symbolic approaches which have been central to developments in artificial intelligence. Well illustrated with case studies, this volume will prove to be an invaluable resource to system scientists, engineers, computer scientists, and members of the medical community.
In a systematic and clear manner, the authors discuss the problems associated with clinical decision making and explore the current methods to solve t...
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605,23 zł |
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Targeting of Drugs 4: Advances in System Constructs
ISBN: 9780306449109 / Angielski / Twarda / 207 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in Cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interaction with the biological milieu, ways by which the latter influences such interaction, strategies by which milieu interference curtailing the function of drug carriers is circumvented and, more recently, with...
The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in...
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605,23 zł |
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Antibiotics: A Multidisciplinary Approach
ISBN: 9780306449246 / Angielski / Twarda / 278 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this translation of the Italian second edition, the authors provide a comprehensive account of the current knowledge on antibiotics. They concisely describe how various scientific disciplines are involved in antibiotics research, development, and use. Their work also discusses the industrial and clinical development of new antibiotics, as well as the questions and controversies related to the function of antibiotics in nature. Antibiotics is richly illustrated with clear chemical structures, drawings, diagrams, and synoptical tables.
In this translation of the Italian second edition, the authors provide a comprehensive account of the current knowledge on antibiotics. They concisely...
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605,23 zł |
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Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis: Volume 2
ISBN: 9780306450181 / Angielski / Twarda / 218 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Comprises 13 chapters, arranged into four sections: pharmacokinetics, pharmacodynamics, pharmacometrics, and pharmacotherapeutics. Topics include the application of disposition decomposition analysis to metabolite kinetics; modeling multiple pharmacodynamic end points; new approaches to self-modelin
Comprises 13 chapters, arranged into four sections: pharmacokinetics, pharmacodynamics, pharmacometrics, and pharmacotherapeutics. Topics include the ...
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605,23 zł |
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Novel Strategies in the Design and Production of Vaccines
ISBN: 9780306452116 / Angielski / Twarda / 198 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the...
Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nev...
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605,23 zł |
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Models for Assessing Drug Absorption and Metabolism
ISBN: 9780306452437 / Angielski / Twarda / 444 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.
Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting bioph...
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806,99 zł |
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Eicosanoids: From Biotechnology to Therapeutic Applications
ISBN: 9780306452864 / Angielski / Twarda / 208 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Among the 18 topics are the lipoxygenases of mice and men, the assessment of pharmacological inhibition of PGH-synthases in man, polymorphonuclear-endothelial cell interactions and the control of coronary vasculature, the clinical application of leukotrience antagonists and synthetase inhibitors in
Among the 18 topics are the lipoxygenases of mice and men, the assessment of pharmacological inhibition of PGH-synthases in man, polymorphonuclear-end...
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605,23 zł |
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Formulation, Characterization, and Stability of Protein Drugs: Case Histories
ISBN: 9780306453328 / Angielski / Twarda / 432 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential hot spots' in proteins, this accessible compilation allows for inspection of the protein's...
Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are desc...
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806,99 zł |
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Bee Products: Properties, Applications, and Apitherapy
ISBN: 9780306455025 / Angielski / Twarda / 269 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The nature .and diversity of presentations at the conference on: "Bee Products: Prop- erties, Applications and Apitherapy" held at Tel-Aviv on May 26--30, 1996, emphasize the increasing interest of physicians, practitioners, scientists, herbalists, dieticians, cosmeti- cians, microbiologists, and beekeepers in different facets of bee products. This volume consists of a selection of 31 contributions presented at the conference and which provide information on the present status of our knowledge in this area. In spite of their diversity, they reflect the mainstream of the conference, namely:...
The nature .and diversity of presentations at the conference on: "Bee Products: Prop- erties, Applications and Apitherapy" held at Tel-Aviv on May 26-...
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928,04 zł |
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Erythrocytes as Drug Carriers in Medicine
ISBN: 9780306455995 / Angielski / Twarda / 150 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The sixth meeting on the use of resealed annealed red blood cells was held in Irsee, Germany by the International Society for the Use of Resealed Erythrocytes (ISURE) on July 25-28, 1996. Although earlier meetings focused on the technology toward develop ment of methods and standardization for efficient, consistent encapsulation, most of the present studies now are directed toward the application use of these carrier blood cells. Basic studies now have been directed toward exploration of commercial applications. In deed, clinical trials were initiated to evaluate the dose-response curves...
The sixth meeting on the use of resealed annealed red blood cells was held in Irsee, Germany by the International Society for the Use of Resealed Eryt...
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806,99 zł |
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Integration of Pharmaceutical Discovery and Development: Case Histories
ISBN: 9780306457432 / Angielski / Twarda / 610 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g., high affinity and specificity for the target receptor), pharmaceutical (e....
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented...
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cena:
806,99 zł |
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Targeting of Drugs 6: Strategies for Stealth Therapeutic Systems
ISBN: 9780306459375 / Angielski / Twarda / 302 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in Cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interactions with the biological milieu, ways by which milieu interference is circumvented, approaches to carrier design or modification that contribute to optimal carrier function, and, more recently, with strategies...
The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in...
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cena:
605,23 zł |
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Immunotoxicology and Risk Assessment
ISBN: 9780306459719 / Angielski / Twarda / 382 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US...
This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on haza...
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806,99 zł |
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Resolving the Antibiotic Paradox: Progress in Understanding Drug Resistance and Development of New Antibiotics
ISBN: 9780306460395 / Angielski / Twarda / 293 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The title of this proceedings comes from the book The Antibiotic Paradox by Stuart B. Levy, referring to the paradox that the more antibiotics are used to treat infectious diseases, the less effective they become. When antibiotics were first introduced, they were considered wonder drugs because they were so effective. But with time bacteria have become resistant to nearly all antibiotics, and resistance is spreading faster than new antibiotics are being developed. This book identifies the issues concerning resistance, as well as describing efforts to develop new drugs that overcome the...
The title of this proceedings comes from the book The Antibiotic Paradox by Stuart B. Levy, referring to the paradox that the more antibiotics are use...
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479,38 zł |
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Membrane Transporters as Drug Targets
ISBN: 9780306460944 / Angielski / Twarda / 530 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure,...
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cena:
806,99 zł |
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