This book provides a detailed description of the Riemann-Hilbert approach (RH approach) to the asymptotic analysis of both continuous and discrete orthogonal polynomials, and applications to random matrix models as well as to the six-vertex model. The RH approach was an important ingredient in the proofs of universality in unitary matrix models. This book gives an introduction to the unitary matrix models and discusses bulk and edge universality. The six-vertex model is an exactly solvable two-dimensional model in statistical physics, and thanks to the Izergin-Korepin formula for the model...