The aim of project work was to develop Self micro-emulsified drug delivery system of nifedipine to increase the solubility in gastric environment to enhance the bioavailability. For suitable development of SMEDDS of nifedipine was studied to know the solubility in various oil, solvent and co-solvent to select the suitable oil and various components for SMEDDS formulation. Nifedipine showed the solubility in sesame oil, tween 80 and propylene glycol. solvent and co-solvent were mixed in various ratios to find the effective ratio for microemulsion formation. At least 26 were developed and only...