This book is recommended for scientists who are willing to improve DoE (Design of Experiments) skills. Nowadays, automation systems are indispensable in scientific measurements and hence Arduino, Raspberry Pi and FPGA are introduced in this book. Here, we have introduced practical examples under the serial and the parallel computing platforms. To strengthen the DoE skills, the examples related to sensors, LEDs, motors, cameras, PWM, WiFi, LoRa, Bluetooth systems...etc, are demonstrated step-by-step. The source code is available at https://github.com/codestorage2021/code