Antimicrobial agents are among the most commonly used and misused of all drugs. The resistance towards available drugs is rapidly becoming a major worldwide problem. The need to design new compounds to deal with this resistance has become one of the most important areas of research today. According to literature survey, thiadiazole is a versatile moiety that exhibits a wide variety of biological activities. Thiadiazole moiety acts as "hydrogen binding domain" and "two-electron donor system". Many drugs containing thiadiazole nucleus are available in the market such as acetazolamide,...