Developments in science and technology have contributed to greater conveniences for human kind; however, the resulting industrial development has required an increased use of heavy metals that contribute to the induction of environmental pollution. Cadmium is a heavy metal with a high toxicity. It is toxic at very low exposure levels and has acute and chronic effects on health and environment. The presented study was carried to evaluate the protective influences of alpha- lipoic acid and melatonin treatment alone and in combination against cadmium toxicity.