In the recent years, cardiovascular and renal diseases have been the most common diseases among the world wide populations; they lead to be taken into consideration among the scientists more than other topics to reach and find new solution that is to help huge numbers illness. So this book is focused on physiological pathways of Endothelin-1 and Angiotensin-II in haemodynamic and renal process, also it is the comprehensive document about Bosentan and Losartan drugs to treat hypertension and kidney failure.