This volume is dedicated to Professor Michael Oberguggenberger at Innsbruck University, Austria, on his 60th birthday. The volume consists of peer-reviewed contributions representing modern trends in the theory of generalized functions and pseudo-differential operators. The collection has been suggested by the ISAAC Group in Generalized Functions (GF) and the ISAAC Group in Pseudo-Differential Operators (IGPDO) which met at the 9th ISAAC congress in Krakow, Poland in August 2013. Topics include Columbeau algebras, ultra-distributions, partial differential equations, micro-local analysis,...