Citrus paradisi commonly known as grapefruit, is considered valuable for its medicinal properties by various traditional systems of medicine and aromatherapy, but no significant work has been conducted on its anxiolytic and antidepressant effects. In the present study, extracts of leaves of Citrus paradisi var. redblush have been evaluated for their CNS activities. Phytochemical and chromatographic profiles of all the leaf extracts have been prepared. The extracts have been evaluated for anxiolytic activity using elevated plus maze model and for antidepressant activity using forced swimming...