Purpose of the study is to develope stable Methotrexate (MTX) loaded Microemulsion based formulation for topical treatment of Psoriasis with improvement in cutaneous deposition and to enhance the local effect. Several treatments of psoriasis are available, each specifically related to certain factors but none of these have curative effects. For practical purposes, patients with less than 15 % body surface involvement can be treated effectively with topical agents. In last few decades there is increasing in understandings of skin & its barrier properties which allowed development of more...