This CCIS volume constitutes the proceedings of the First International Conference on Computational Systems Biology and Bioinformatics (CSBio 2010), held in Bangkok, Thailand, November 3 5, 2010. CSBio 2010 was a follow up to the successful Special th Session on Computational Advances in Bioinformatics (CAB 2009) in the 16 International Conference on Neural Information Processing (ICONIP 2009). CSBio will provide an annual forum for international researchers to exchange the latest ideas on advances in the interdisciplinary fields of computational systems biology and bioinformatics. CSBio is...