This volume presents the final case studies in the Innovation Systems Research Network's (ISRN) five-year investigation of twenty-six industry clusters across Canada. Contributors describe clusters in Toronto, Sudbury, and the Okanogan and in biotechnology, tool and die making, and mining services. They argue that in attempting to craft policies that help existing clusters adjust to differences in institutional linkages, knowledge dimensions, and cluster growth, policy makers must account for historically rooted institutional dynamics and the influence of regional culture.