With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent...

Several years ago a friendly looking young man walked into my office at the University Department of Dermatology in Cologne, introduced himself as a diplomate chemist, executive member of a family-owned, rather small German company manufacturing hair care products, and proposed to me straight forward to organize an international meeting on hair research. In view of the large number of new developments in the field something like this should be done after all, he said; he also promised to provide financial support. Such a meeting should be on the highest possible level, I said; and he agreed....

Durch detaillierte Therapieempfehlungen zum gesamten Spektrum der Hautkrankheiten, einschliesslich Venerologie, HIV-Infektion, Andrologie, Phlebologie und Proktologie, ist das Buch fur jeden im weitesten Sinne dermatologisch tatigen Arzt ein unentbehrlicher Ratgeber. Unterschiedliche Krankheitsauspragungen, Schweregrade und Patientencharakteristika sind bei den Behandlungsvorschlagen berucksichtigt. Neben den Standardtherapien werden auch neue und experimentelle Therapieansatze beschrieben und bewertet. Die zweite Auflage wurde komplett aktualisiert und um Kapitel uber allergische Rhinitis,...