This volume contains commentary on the text from Partition 1, Section 2, Member 4, Subscription 1 to the end of the second Partition. It thus includes Burton's account of the causes, symptoms, and prognosis of melancholy, and his examination of remedies, spiritual and medical.

This, the final volume of the Clarendon Press edition of Burton's Anatomy of Melancholy, contains commentary on the Third Partition, in which Burton considers two especial forms of the disease, Love and Religious Melancholy. The volume includes an index which gives biographical and bibliographical information concerning the more than 1550 authorities cited in the Anatomy, most of whom are little known today. Also included are an index of the major topics discussed in the Anatomy, and a complete bibliography of all the works mentioned in the commentary.