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Both radiotherapy and chemotherapy exert damaging effects on normal tissues in cancer patients and, consequently, induce an immune response in these tissues. Ionizing radiation in interaction with living cells causes a variety of changes depending on type of exposure, absorbed dose, duration of exposure, interval after exposure and also susceptibility of tissues.Taking into account that BM-derived cells are responsible of maintaining, generating, and replacing differentiated cells as a consequence of physiological cell turnover or tissue damage due to injury.