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This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical...

Nature is the mother of all culture, human-being and their portrait civilization is the fen of that culture. The deterministic perception of man is the core of nature oriented culture. Though the nano-science and meta-physics deal everything in our life but sometimes they fail to fulfill the perception of populace and the restoration of the eco-health of environment. More than dozen of conferences and world summit have been organized but they failed to restore the traditional culture as well as the health of environment. Cultural clash and mixed culture reduced the folk traditions, nature...