Eukaryotic Rnases and Their Partners in RNA Degradation and Biogenesis: Part a Volume 31

ISBN-13: 9780124047402 / Angielski / Twarda / 2012 / 278 str.

Guillaume Chanfreau

Opis

This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

Spis treści

1. Biochemistry and Function of RNA Exosomes

Michal Lubas, Aleksander Chlebowski, Andrzej Dziembowski and Torben Heick Jensen

1. Plant Exosomes and Cofactors

Heike Lange and Dominique Gagliardi

2. Structure and Activities of the Eukaryotic RNA Exosome

Elizabeth V. Wasmuth and Christopher D. Lima

3. TRAMP Stimulation of Exosome

Peter Holub and Stepanka Vanacova

4. XRN1: A Major 5' to 3' Exoribonuclease in Eukaryotic Cells

Sarah Geisler and Jeff Coller

1. Structures of 5'-3' Exoribonucleases (XRNs)

Jeong Ho Chang, Song Xiang and Liang Tong

2. The Diverse Functions of the Nuclear Rat1/Xrn2 Exonuclease

Michal Krzyszton, Monika Zakrzewska-Placzek, Michal Koper and Joanna Kufel

3. Normal and Aberrantly Capped mRNA Decapping

Megerditch Kiledjian, Mi Zhou and Xinfu Jiao

4. Activity and Function of Deadenylases

Christiane Harnisch, Bodo Moritz, Christiane Rammelt, Claudia Temme and Elmar Wahle

5. The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism

Kevin Roy and Guillaume F. Chanfreau

O autorze

Dr Guillaume Chanfreau obtained his Bachelor Degree from Université Claude Bernard Lyon and ENS Lyon and his PhD in Microbiology from Université Paris VI. During his PhD, mentored by Alain Jacquier, he characterized the mechanism of splicing of group II intron ribozymes. Dr Chanfreau then completed postdoctoral training at UCSF with Christine Guthrie, where he identified novel factors involved in 3'-end processing of mRNAs and small RNAs. After this postdoctoral training, he was recruited at UCLA as a professor in the Department of Chemistry and Biochemistry where he teaches a Biochemistry upper division course focused on DNA, RNA and protein synthesis. At UCLA, Dr Chanfreau has developed a research program focused on understanding the mechanisms of RNA degradation and RNA processing, and how these processes contribute to regulate gene expression. Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.