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Although intensive research and prevention measures have been carried out for decades to control bovine mastitis, it continues to cause the biggest economic impact to the dairy industry worldwide. Therefore, it is of great importance to investigate biomarkers that could be used for rapid detection of mastitis. The discovery of new biomarkers which allow the clinical monitoring of different diseases is nowadays encouraged in order to improve the diagnosis, evaluation, treatment and therapeutics in each phase of the disease. Therefore, the use of acute phase proteins in the diagnosis of...

Acute phase proteins (APPs) have been used as biomarkers of diseases for decades in human medicine, but were relatively under-utilised in the veterinary medicine. Over recent years, significant progress have been made in studies on acute phase response in farm animals and small animals medicine, including the detection, measurement, and application of APPs as biomarkers of diseases. APPs are blood and milk proteins, primarily synthetized by hepatocytes and mammary gland tissue cells as a part of acute phase response. The acute phase response is a complex systemic early-defence system...