Dendrimers in Nanomedicine

ISBN-13: 9789814745499 / Angielski / Twarda / 2016 / 420 str.

Delphine Felder-Flesch

Opis

Nanomedicine can take advantage of the recent developments in nanobiotechnology research for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles, and improved accumulation at the disease site. This book provides a broad glimpse of how various dendritic nanomaterials have been designed and used as efficient tools for nanomedicine. It comprises a pedagogic introduction to dendrimers and hyperbranched systems and their classical and accelerated syntheses through cutting-edge methodologies. The chapters on dendronized magnetic nanoparticles as theranostics, dendrimers in theory (molecular simulations), siRNA delivery with dendrimers, and dendrimers for image-guided therapy, combined with chapters focused on specific types of dendrimers or hyperbranched structures, detail the cutting-edge research in nanomedicine. Finally, a detailed chapter on issues related to the pharmacokinetics and biodistribution of dendrimers helps choose the right structures for successful transfer from bench to bedside. This book will appeal to those involved in nanobiotechnology, macromolecular science, cancer therapy, tissue repair, and siRNA delivery research.

Spis treści

General introduction: classical versus accelerated syntheses of dendrimers. Dendrimer-nanoparticle conjugates. Dendritic polymers for the repair of tissues. Polyglycerols in Nanomedicine. Theranostic dendronized iron oxide nanoparticles. Anti-inflammatory dendrimers. Dendrimers for siRNA delivery. Dendrimers in cancer therapy. Dendrimer pharmacokinetics and biodistribution. Molecular modeling of dendrimers.

O autorze

Delphine Felder-Flesch obtained her PhD in supramolecular organic chemistry from the University of Strasbourg, France, in 2001. After an Erasmus training period at the University of York, England, she started post-doctoral research at the ETH-Zürich, Switzerland, in the group of Prof. Dr. F. Diederich. Since October 2003, she is a CNRS research scientist at the Institute of Physics and Chemistry of Materials Strasbourg, France. Her main research interests include (ME)MRI or nuclear medicine dendritic nanoprobes for efficient in vivo tumor targeting and cancer early diagnosis imaging. She also develops, in collaboration with solid state chemists, dendronized nanoparticles as MRI nanoprobes and for magnetic hyperthermia treatment of cancers.