Wiley Encyclopedia of Chemical Biology

ISBN-13: 9780471754770 / Angielski / Twarda / 2008 / 3188 str.

Tadhg P. Begley

Opis

The Wiley Encyclopedia of Chemical Biology is an authoritative new work whose goal is to illuminate the crucial role of chemistry and chemical techniques in the life sciences. The encyclopedia will adopt an inclusive editorial approach, encompassing fundamental and blue-sky science as well as those areas of research that have more immediate medical or commercial applications. The scope and structure of the work will reflect the multidimensional character of chemical biology, focusing in particular on the fundamental science of biological structures and systems, the use of chemical and biological techniques to elucidate that science, and the applications of this knowledge in areas as diverse as drug discovery, sensor technology, and catalysis. Major topics areas covered in the encyclopedia:

• Chemical Views of Biology
• Biomolecules within the Cell
• Chemistry of Biological Processes and Systems
• Chemical Biology of Cellular Compartments
• Synthetic Molecules as Tools for Chemical Biology
• Technologies and Techniques in Chemical Biology
• Applications of Chemical Biology

Recenzje

"This book is an excellent compilation of various topics in chemical biology. The chapters are written by experts in the field and are self–explanatory. The book is essential reading for researchers in chemical biology."  ( Analytical and Bioanalytical Chemistry, Jan – June 2010)

If we needed one, perhaps this is the bible of chemical biology. It should find its place in any chemistry or biology library because it provides a very strong entry into a number of important and contemporary research topics and methods that are relevant to both fields, and constitute the essence of chemical biology. (ChemBioChem, October 2009)

Spis treści

ADME properties of drugs.

AdoMet–dependent methyltransferases, Chemistry of.

Alkaloid Biosynthesis.

Allergy and Asthma, Small Molecules to Target.

Amino Acids, Chemical Properties of.

Aminoacyl tRNA Synthetases, Chemistry of.

Amyloid Formation.

Antibiotics, Bacterial Resistance to.

Antibiotics, Biosynthesis of.

Anxiety Disorders, Macromolecular Pathways and Interactions.

Apoptosome and Caspase Activation.

Artificial Metalloproteins, Design and Engineering of.

ATP Synthesis, Chemistry of.

Attenuation, Control of Gene Expression by.

B12–Dependent Enzyme Reactions, Chemistry of.

Bacterial DNA Polymerases, Chemistry of.

Bacteriorhodopsin, Chemistry of.

Biocatalysis and Biotransformation.

Biocatalysts and Chemocatalysts in the Pharmaceutical Industry.

Biocompatibility of Materials in Medical Devices.

Calcium Pump, Chemistry of.

Calcium Signaling.

Carbohydrate–Carbohydrate Interactions.

Catalytic Antibodies (abzymes), Synthetic.

Catalytic Modes in Natural Ribozymes.

Cell Cycle, Regulation of.

Cell Death, Biological Mechanisms and Small Molecule Inhibitors of.

Cell Membranes, Dynamics of.

Cellular Energy Metabolism and Integrated Oxidative Phosphorylation.

Chaperones, Molecular.

Chemical Libraries to Screen for Biologically Active Small Molecules.

Chemical Molecules that Regulate Transcription and Facilitate Cell–to–Cell Communication.

Chlorophylls and Carotenoids, Chemistry of.

Chromosome Formation.

Chronic Obstructive Pulmonary Disease (COPD), Mechanisms of.

Circular Dichroism for Natural Products.

Click Peptides, Design and Applications of.

CoA–Dependent Enzymes, Chemistry of.

Cofactor Biosynthesis.

Collagen Triple Helix, Stability of.

Combinatorial Libraries: Overview of Applications in Chemical Biology.

Controlled Drug Delivery: Pharmacokinetic Considerations, Methods and Systems.

Cyclooxygenase Inhibition, Recent Advances in the Mechanisms of.

Cytochrome P450 Monooxygenases, Chemistry of.

Cytosolic Glycosylated Proteins, Chemistry of.

Depression, Chemical Mechanisms of.

Differential Scanning Calorimetry to Study Lipids and Lipid Membranes.

Directed Evolution, Novel and Improved Enzymes through.

DNA Damage Repair, Chemistry of.

DNA Damage, Sensing of.

DNA Helicases, Chemistry and Mechanisms of.

DNA Polymorphisms, Tools to Detect.

DNA Transposition: Topics in Chemical Biology.

DNA–Conjugated Organic Chromophores in DNA Stacking Interactions.

Drug Design Strategies for Targeting G–Protein–Coupled Receptors.

Drug Discovery and Development, Computational Approaches in.

Drug Transport in Living Systems.

Electron paramagnetic resonance (EPR) in Enzymology.

Electron Transfer, Chemical Roles of Water in.

Endocytosis, Receptor–Mediated.

Endoplasmic Reticulum: Topics in Chemical Biology.

Enzymatic Synthesis of Carbohydrate–Containing Biomolecules.

Enzyme Catalysis, Chemical Strategies for.

Enzyme Inhibition, Approaches to.

Enzyme Kinetics.

Epigenetic Modifications.

Essential Fatty Acids, Physiology and Clinical Significance of.

Fatty Acid Desaturases, Chemistry of.

Flavin–Mediated Hydroxylation Reactions.

Flavoenzymes, Chemistry of.

Fluorescence in Living Systems: Overview of Applications in Chemical Biology.

Fluorescence Spectroscopy: Overview of Applications in Chemical Biology.

Fluorescence Techniques for Proteins.

Fluorescence to Study Nucleic Acids.

Förster Resonance Energy Transfer (FRET) for Proteins.

Forward Chemical Genetics.

Glycan Biosynthesis in Mammals.

Glycan Synthesis, Key Strategies for.

Glycans, Array–Based Techniques for.

Glycoconjugate Structure and Biosynthesis.

Glycosphingolipids, Chemistry of.

Glycosylation of Proteins in the Golgi Apparatus.

Glycosyltransferases, Chemistry of.

Group II Introns: Stucture, Function, and Catalysis.

Hemes in Biology.

Hemozoin: A Paradigm for Biominerals in Disease.

High Throughput Screening (HTS) Techniques: Overview of Applications in Chemical Biology.

Histone Modifications, Chemistry and Structural Consequences of.

Hormone Signaling.

Human Hemoglobin: Identification of a Key Intermediate.

Hydration Forces: Water and Biomolecules.

Hypoxic Response and Associated Diseases.

Informatics for Glycans.

Inorganic Chemistry in Biology.

Inositol Phosphates.

Inositol Phospholipids, Biosynthesis and Biological Functions of.

Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling.

Integrin Signaling.

Intramembrane Proteolysis.

Ion Channels.

Ion Channels in Medicine.

Ion Channels, Computations of.

Iron–Sulfur Clusters, Properties and Functions of.

Iron–Sulfur World.

Isoprostanes.

Kinases and Dephosphorylases, Chemistry and Roles of.

Lantibiotics, Biosynthesis and Modes of Action of.

Large G–Proteins.

Lead Optimization in Drug Discovery.

Lipid Bilayers, Properties of.

Lipid Domains, Chemistry of.

Lipid Homeostasis, Chemistry of.

Lipid Signals, Extracellular.

Lipidated peptide synthesis.

Lipidomics.

Lipids, Chemical Diversity of.

Lipids, Organization and Aggregation of.

Lipids, Phase Transitions of.

Locked Nucleic Acids.

Lysosomal Disorders.

Marine Natural Products, Chemical Diversity of.

Mass Spectrometry of Fatty Acid Peroxidation Products.

Mass Spectrometry to Identify Post–Translational Modifications.

Mass Spectrometry, Applications in Proteomics of.

Mathematical Modeling of Biological Signaling Networks.

Mechanosensitive Channels.

Membrane Potentials in Living Systems, Tools to Measure.

Membrane Protein Structure, Techniques to Study.

Membrane Proteins, Properties of.

Membrane Trafficking.

Membranes, Fluidity of.

Metabolic Diseases, Biological Mechanisms of.

Metabolism, Cellular Organization of.

Metabolome.

Metal Homeostasis.

Metallo–Enzymes and Metallo–Proteins, Chemistry of.

Metallointercalators as Probes of DNA Recognition and Reactions.

Metalloproteinases, Biophysics and Chemistry of.

Metalloregulatory Proteins.

Metals in Medicine, Imaging Agents.

Metals in Medicine, Therapeutic Agents.

Methylerythritol Phosphate Pathway for Formation of Isoprene Units.

Microarrays in Chemical Biology.

MicroRNA.

Microtubule Dynamics.

Mitochondrial Medicine, Biochemical Evaluation of Mitochondrial Function.

Mitogen–activated Protein Kinases (MAPKs): ERKs, JNKs, and p38s.

Modified Nucleosides in RNA.

Molecular Recognition, Computation and Modeling of.

NAD(P) Dependent Dehydrogenases.

Natural and Unnatural Amino Acids, Synthesis of.

Natural Products as Anticancer Agents.

Natural Products in Plants, Chemical Diversity of.

Natural Products: An Overview.

Naturally Occurring Peptide Hormones and Neurotransmitters, Synthesis of.

Nature: A Model System for Chemists.

Neocarzinostatin, Protein–Small Molecule Interactions.

Neoglycoproteins, Chemistry of.

Neuropeptides, Chemical Activity Profiling and Proteomic Approaches for.

Neurotransmission, Measuring Chemical Events in.

Neurotransmitter Release.

Nitric Oxide, Biological Targets of.

NMR for Proteins.

NMR of Lipids.

NMR: Overview of Applications in Chemical Biology.

NMR–Based Metabolomics Technology in Biomarker Research.

Non–Homologous Recombination.

Nonribosomal Peptides, Biosynthesis of.

Nuclear Receptors, Chemistry of.

Nucleic Acid Enzymes (Ribozymes and Deoxyribozymes), In Vitro Selection and Application of.

Nucleic Acids, Chemical Damage to.

Nucleic Acids, Hydration of.

Nucleobase Self–assembly Codes, Constitutional Transcription of.

Olfaction: Topics in Chemical Biology.

Origins of Life: Emergence of Amino Acids.

Origins of Life: Emergence of the RNA World.

Oxygen–Activating Enzymes, Chemistry of.

Paramagnetic Metalloproteins, NMR Spectroscopy of.

Passive Diffusion across Membranes.

Pathogen–Host Interactions, Chemical Biology Approach to.

Pentose Phosphate Pathway.

Peptide Combinatorial Libraries.

Peptide Nucleic Acids (PNAs).

Peptide Synthesis, Coupling Methods for.

Peptidomimetics.

Pharmaceuticals: Natural Products and Natural Product Models.

Pharmacokinetics of Drug Candidates, Determination of.

Phosphate Mimics, Cyclic Compounds as.

Photosynthesis, Electron Transfer Chemistry in.

Physical Chemistry in Biology.

Physico–Chemical Properties of Nucleic Acids: Character and Recognition of Watson–Crick Base Pairs.

Plant Terpenoids.

Plant–Derived Natural Products Research, Recent Progress in Drug Discovery.

Platinum Anticancer Drugs, Chemical Biology of.

PLP–Dependent Enzymes, Chemistry of.

Polyketide Biosynthesis, Fungi.

Polyketide Biosynthesis, Modular Polyketide Synthases.

Polyketide Biosynthesis, Polyethers.

Polymer Therapeutics.

Polymerase Chain Reaction (PCR) in Chemical Biology.

Post–Translational Modifications to Regulate Protein Function.

Pre–mRNA splicing.

Programmed Cell Death as a Therapeutic Approach.

Protease Inhibitors, Mechanisms of.

Proteasome, Chemistry of.

Protein and DNA Thermostability, Physics and Evolution of.

Protein Folding, Energetics of.

Protein Misfolding and Disease, Chemical Biology of.

Protein Trafficking Diseases, Small Molecule Approaches to.

Protein–Protein Interactions.

Protein–Protein Interactions with Small Molecules, Modulation of.

Proteins, Array–Based Techniques for.

Proteins, Chemistry and Chemical Reactivity of.

Proteins: Computational Analysis of Structure, Function and Stability.

Quorum Sensing.

Ras Oncoproteins: Structure, Biochemistry and Biology of.

Receptor–Ligand Interactions in Biological Systems.

Ribosome, Chemistry of.

RNA Interference to Treat Human Diseases, Applications of.

RNA Interference, Mechanisms and Proteins Involved in.

RNA Stability, Chemistry, Measurement and Modulation of.

RNA, Noncoding.

Saliva in Health and Disease, Chemical Biology of.

Schizophrenia, Biological Mechanisms of.

Second Messengers in Cellular Signaling.

Serine Proteases and Serine Protease Inhibitors.

Signaling Networks in Biology.

Single–Molecule Studies of Biomolecules.

Small Molecule Inhibitors, Design and Selection of.

Solid–Phase Synthesis of Biomolecules.

Starch Biosynthesis in Plants.

Stem Cell Fates, Small Molecules to Control.

Stereochemistry of Biological Molecules.

Steroid Hormones, Biology and Biochemistry of.

Supported Lipid Bilayers, Development and Applications in Chemical Biology of.

Symbiosis: Topics in Chemical Biology.

Synthetic Chemistry: Formation of the Amide Bond.

Synthetic Peptide Templates for Molecular Recognition, Recent Advances and Applications of.

Synthetic Peptides and Proteins to Elucidate Biological Function.

Synthetic Sphingolipids as Bioactive Molecules.

Systems Approach to Metabolism.

Systems Approach to Studying Disease.

Taste: Topics in Chemical Biology.

Terpenoids in Plant Signaling, Chemical Ecology.

Thrombin.

Tissues and Organs, Synthesis of.

Transcript Profiling, Tools for.

Transcription Factors.

Transcription, Initiation of.

Transcription–Based Therapeutics.

Transient State Enzyme Kinetics.

Translational Recoding.

Tumor Cell Energetic Metabolome.

Two– and Three– Hybrid Systems.

Ubiquitin Proteasome Pathway.

Unnatural Amino Acids to Investigate Biological Processes.

Unraveling Cell Division Mechanisms with Small–Molecule Inhibitors.

Viral Cysteine Peptidases and Cysteine Peptidase Inhibitors.

Water in Biological Recognition Processes, Roles of.

Water, Properties of.

Xenobiotic Metabolism.

O autorze

Tadhg P. Begley is Professor of Chemistry and Chemical Biology at Cornell University. Begley (PhD, California Institute of Technology, 1983) is a leading figure in the chemical biology community. He is the recipient of a number of awards for teaching and research, including the Merck Faculty Development Award and the Camille and Henry Dreyfus Teacher–Scholar Award.