Water-Insoluble Drug Formulation

ISBN-13: 9781498729413 / Angielski / Twarda / 2018 / 736 str.

Ron Liu

Opis

A drug molecule has to be water soluble to be readily delivered to the cellular membrane but needs to be hydrophobic to cross the membrane. Delivering drugs in water-insoluble formulation is thus a critical matter in therapeutic drug development. This book serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. Reflecting the significant progress and advances since the last edition, this edition revises and updates all of the chapters.

Spis treści

Introduction. Solubility Theory. Prediction of Solubility. Preformulation Aspects of Insoluble Compounds. Water-Insoluble Drugs and Their Pharmacokinetic Behaviors. Regulatory Aspects of Dissolution for Low Solubility Drug Products. Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support. Application of Complexation in Drug Development for Insoluble Compounds. Solubilization Using Cosolvent Approach. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery・Part I: Parenteral Applications. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery・Part II: Oral Applications. Micellization and Drug Solubility Enhancement. Polymeric Micelles in Water-Insoluble Drug Delivery. Liposomes in Solubilization. Pharmaceutical Salts. Prodrugs for Improved Solubility in Water. Particle Size Reduction. Development of Solid Dispersion for Poorly Water-Soluble Drugs. Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms. Pharmaceutical Powder Technology・ICH Q8 and Building the Pyramid of Knowledge. Soft Gelatin Capsules Development. Oral Modified-Release Drug Delivery for Water-Insoluble Drugs. Scalable Manufacturing of Water-Insoluble Drug Products. Index.

O autorze

Ron Liu is CEO of AustarPharma, a pharmaceutical company based in Edison, New Jersey.