Viral Vector Approaches in Neurobiology and Brain Diseases

ISBN-13: 9781493959433 / Angielski / Miękka / 2016 / 347 str.

Riccardo Brambilla

Opis

This book covers key aspects related to the use of viral vectors in neurobiology, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain diseases.

Spis treści

Part I: Types of Viral Vectors in Neuroscience Research

 

1. Lentiviral Vectors as Research Tools in Neurobiology: Design and Production

            Alessandro Papale and Riccardo Brambilla

 

2. Recombinant Adenovirus in Neurobiology

            Qian Li and Tong-Chuan He

 

3. Adeno-Associated Virus-Based Vectors

            Nathalie Dutheil and Erwan Bezard

 

4. Herpes Simplex Virus 1 (HSV-1)-Based Vectors

            Aldo Pourchet, Matias E. Melendez, Anna Greco, and Alberto L. Epstein

 

5. Alphavirus-Based Vectors

            Kenneth Lundstrom

 

Part II: Viral Vectors in Memory Research and Psychiatric Diseases

 

6. Viral Vectors to Study Synaptic Function

            Hélène Marie

 

7. Using Viral Vectors to Study the Memory Trace in Mice

            Asim J. Rashid, Chen Yan, and Sheena A. Josselyn

 

8. Development of Cell-Type Specific Viral Vectors to Tease Apart the Neural Circuitry that Contributes to Drug Addiction

            Susan M. Ferguson and John F. Neumaier

 

9. Using Viral-Mediated Gene Transfer to Study Depressive-Like Behavior

            Amy R. Furay and John F. Neumaier

 

Part III: Viral Vectors in Neurological Disorders

 

10. Gene Therapy for Parkinson’s Disease

            Erika Elgstrand Wettergren, Luis Quintino, Giuseppe Manfré, and Cecilia Lundberg

 

11. Lentiviral Vectors in Huntington’s Disease Research and Therapy

            Aurélie Delzor, Noëlle Dufour, and Nicole Déglon

 

12. Application of Viral Vectors to Motor Neuron Disorders

            Elisabeth Dirren and Bernard L. Schneider

 

Part IV: Applications of Viral Vector Technology to Neuroscience Research

 

13. In Vivo Gene Silencing by Virally Delivered MicroRNA

            Eugenia V. Gurevich, Mohamed R. Ahmed, and Yonatan Carl

 

14. Viral Manipulation of Neural Stem/Precursor Cells

            Nunzio Iraci, Giulia Elisabetta Tyzack, Chiara Cossetti, Clara Alfaro-Cervello, and Stefano Pluchino

 

15. Viral Vector-Based Techniques for Optogenetic Modulation In Vivo

            Mathias Mahn, Shiri Ron, and Ofer Yizhar

 

16. Viral Vectors for Optogenetics of Hypothalamic Neuropeptides

            H. Sophie Knobloch, Alexander Charlet, Ron Stoop, and Valery Grinevich

 

17. Viral Vectors in Primate Research: Examples from Parkinson's Disease Research

            Grégory Porras, Benjamin Dehay, and Erwan Bezard

Blurb

Aiming toward improvement in the safety, efficiency, and specificity of viral vectors for neurobiological research and clinical applications, Viral Vector Approaches in Neurobiology and Brain Diseases covers key aspects related to the use of viral vectors in neuroscience, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain disorders.  The volume begins by delving into features of the viral vectors currently available in neuroscience and their production methods, and it then continues onward to examples of successful applications of viral vector technology to psychiatric and memory research, current applications of viral vector technology in the context of neurological disorders, as well as various cutting-edge applications of viral vector technology to neuroscience, including optogenetics.  Written for the Neuromethods series, the chapters of this book contain the kind of detailed description and implementation advice that promotes successful, repeatable results.

 

Practical and up to date, Viral Vector Approaches in Neurobiology and Brain Diseases will be useful not only to neurobiologists wishing to routinely use viral vectors in the laboratory but also to experienced scientists needing detailed new protocols for a variety of experimental applications.