Translational Medicine: The Future of Therapy?

ISBN-13: 9789814316996 / Angielski / Twarda / 2013 / 294 str.

James Mittra; Christopher-Paul Milne

Opis

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Recenzje

"This is a book that should be read by all those aiming to improve the efficiency and effectiveness of translation of science into clinical practice and health outcomes. Unlike other contributions in the field, it takes a holistic approach to the problem and recognises the dynamic nature of demand for as well as supply of health innovation, identifying strategies to integrate the two. This book has been needed for some time, but, with stagnating productivity and ever-increasing economic pressures, never more so than right now."
—Prof. Iain Gillespie, The University of Edinburgh, UK

Spis treści

Introduction: Introduction to Translational Medicine. Drivers and Barriers to Translational Medicine: New Light Through an Old Window? The "Translational Turn" in Biomedical Research — A Historical Perspective. Translational Medicine: The Industry Perspective. Drivers and Barriers of Translational Medicine: A Regulatory Perspective. Developing an Evaluation Model for Translational Medicine Research Programs. State of the Art in Science and Technology: Emerging Concepts in Biomarker Discovery: Cancer Immunotherapy and Degenerative Diseases of the Eye as Model Systems. Imaging Biomarkers for Innovative Drug Development: Translation from Bench to Bedside and Back. Translational Bioinformatics: Bridging the Biological and Clinical Divide. Institutional Dynamics of Translational Medicine: Exploiting Translational Medicine Through Public–Private Partnerships: A Case Study of Scotland’s Translational Medicine Research Collaboration (TMRC). The Role of the Product Development Partnership as a Translational Mechanism for Delivering Health Solutions in Low-Resource Settings. Conclusions: Is Translational Medicine the Future of Therapy?