Translation and Its Regulation in Cancer Biology and Medicine

ISBN-13: 9789402403510 / Angielski / Miękka / 2016 / 697 str.

Armen Parsyan

Opis

This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Spis treści

Preface

1 Introduction

PART I. TRANSALATION MACHINERY IN CANCER

2 Mechanism of Translation in Eukaryotes

3 Diverse Mechanisms of Translation Regulation and Their Role in Cancer

4 eIF4E and Its Binding Proteins

5 RNA Helicases and Their Cofactors

6 PDCD4

7 eIF4G

8 eIF3

9 The eIF2 Complex and eIF2α

10 eIF5A

11  eIF6

12 Translation Elongation

13 Ribosomes

14 Current and Emerging Therapies Targeting Translation

PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER

15 mTOR and Regulation of Translation

16 Ribosomal Protein S6 and S6 Kinases

17 eIF4E Phosphorylation Downstream of MAPK Pathway

PART III. CELL FATE AND TRANSLATION IN CANCER

18 Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells

19 Translation and Apoptosis in Cancer

20 Translation in Cancer at Hypoxia

PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES

21 Melanoma and Non-Melanoma Skin Cancers

22 Sarcomas

23 Hematological Malignancies and Premalignant Conditions

24 Brain Tumors

25 Head and Neck Cancers

26 Breast Cancer

27 Cancers of the Respiratory System

28 Gastric and Esophageal Cancers

29 Colorectal Cancers

30 Hepatic, Pancreatic and Biliary Cancers

31 Pancreatic Neuroendocrine Tumors

32 Gynecologic Cancers

33 Prostate Cancer

34 Cancers of the Urinary System

List of Abbreviations