The Neuronal Environment: Brain Homeostasis in Health and Disease

ISBN-13: 9781617372353 / Angielski / Miękka / 2010 / 444 str.

Wolfgang Walz

Opis

Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.

Recenzje

"This book is a timely collection of reviews of fundamental processes in the compartments and chemical components of the cerebral micro-environments...its contents prove rewarding reading for the neuroclinician." - Clinical Neurology and Neurosurgery

"The book targets researchers, graduate students, and educators who face constant challenges on how to modify the external environment of a specific neuron in order to obtain specific behavioral results. The author is a credible authority on the subject but I think the scope of the book has an audience beyond that proposed by the author. Neurology and neurosurgery residents would also find it useful to read this book in order to better understand the mechanisms of control of the central nervous system...This is a good contribution to the field of neuroscience. Besides the initial aim signaled by the authors, I would extend the list of readers to neurology and neurosurgery residents, who are daily questioned on the genetic-physiologic correlation of diseases dealt with on a daily basis." -Doody's Health Sciences Book Review Journal

"...not just a textbook on neuroscience, as readers might imagine from the book title, but rather an essential guide for experts, beginners and students in the field of cell biology and pharmacology...written by experts who have made major contributions in their field..." - Journal of Chemical Neuroanatomy

"...this volume is not just a textbook on neuroscience, as readers might imagine from the book title, but rather an essential guide for exerts, beginners and students in the field of cell biology and pharmacology...written by experts who have made major contributions in their field..." - Journal of Chemical Neuroanatomy

"Once one begins to read in greater depth, it becomes clear that this volume is not just a textbook on neuroscience, as readers might imagine from the book title, but rather an essential guide for experts, beginners and students in the field of cell biology and pharmacology...written by experts who have made major contributions in their field...this book, besides being an excellent learning tool, is to enjoy." -Elsevier

Spis treści

I. Neuronal Activity and Its Dependence on the Microenvironment Central Nervous System Microenvironment and Neuronal Excitability Stephen Dombrowski, Imad Najm, and Damir Janigro Neuronal Energy Requirements Avital Schurr II. Brain Microenvironment Plasticity of the Extracellular Space Eva Syková Transmitter-Receptor Mismatches in Central Dopamine, Serotonin, and Neuropeptide Systems: Further Evidence for Volume Transmission Anders Jansson, Laurent Descarries, Virginia Cornea-Hébert, Mustapha Riad, Daniel Vergé, Mircea Bancila, Luigi Francesco Agnati, and Kjell Fuxe The Extracellular Matrix in Neural Development, Plasticity, and Regeneration Jeremy Garwood, Nicolas Heck, Franck Rigato, and Andreas Faissner Homeostatic Properties of Astrocytes Wolfgang Walz and Bernhard H. J. Juurlink Glutamate-Mediated Astrocyte-Neuron Communication in Brain Physiology and Pathology Micaela Zonta and Giorgio Carmignoto Axonal Conduction and Myelin Jeffrey D. Kocsis Coupling of Blood Flow to Neuronal Excitability Albert Gjedde III. Brain Macroenvironment Choroid Plexus and the Cerebrospinal-Interstitial Fluid System Roy O. Weller The Blood-Brain Barrier Richard F. Keep Circumventricular Organs James W. Anderson and Alastair V. Ferguson Glial Linings of the Brain Marc R. Del Bigio IV. Immune System-Neuron Interactions Microglia in the CNS Sophie Chabot and V. Wee Yong Invasion of Ischemic Brain by Immune Cells Hiroyuki Kato and Takanori Oikawa

Blurb

To function properly, neurons must interact with other constituent elements of the brain (e.g., blood supply and myelin), and in fact most diseases of the nervous system involve these nonneuronal components. In The Neuronal Environment: Brain Homeostasis in Health and Disease, leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, ion homeostasis, and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system, which controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in blood-brain barrier function, and inflammation and the neuroimmune system. All these elements are treated in the context of their importance for neurons and the major diseases affecting them.
Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates for today's neuroscientists, cell biologists, and pharmacologists a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the brain's sole information processing system.