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Kategorie szczegółowe BISAC

The Herpesviruses

ISBN-13: 9781468441659 / Angielski / Miękka / 2013 / 445 str.

Bernard Roizman
The Herpesviruses Bernard Roizman 9781468441659 Springer - książkaWidoczna okładka, to zdjęcie poglądowe, a rzeczywista szata graficzna może różnić się od prezentowanej.

The Herpesviruses

ISBN-13: 9781468441659 / Angielski / Miękka / 2013 / 445 str.

Bernard Roizman
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The first volume of the nineteen-volume series entitled Comprehensive Virology was published in 1974 and the last is yet to appear. We noted in 1974 that virology as a discipline had passed through its descriptive and phenomenological phases and was joining the molecular biology rev- olution. The volumes published to date were meant to serve as an in- depth analysis and standard reference of the evolving field of virology. We felt that viruses as biological entities had to be considered in the context of the broader fields of molecular and cellular biology. In fact, we felt then, and feel even more strongly now, that viruses, being simpler biological models, could serve as valuable probes for investigating the biology of the far more complex host cell. During the decade-long compilation of a series of books like Com- prehensive Virology, some of the coverage will obviously not remain up- to-date. The usual remedy to this aspect of science publishing is to pro- duce a second edition. However, in view of the enormous increase in knowledge about viruses, we felt that a new approach was needed in covering virology in the 1980s and 1990s. Thus we decided to abandon the somewhat arbitrary subgrouping of the subject matter under the titles Reproduction, Structure and Assembly, Regulation and Genetics, Addi- tional Topics, and Virus-Host Interactions. Instead we have organized a new series entitled The Viruses.

Kategorie:
Nauka, Medycyna
Kategorie BISAC:
Medical > Choroby zakaźne
Science > Botanika
Science > Mikrobiologia
Wydawca:
Springer
Seria wydawnicza:
Viruses
Język:
Angielski
ISBN-13:
9781468441659
Rok wydania:
2013
Wydanie:
1982
Numer serii:
000076407
Ilość stron:
445
Waga:
0.88 kg
Wymiary:
25.4 x 17.8
Oprawa:
Miękka
Wolumenów:
01

1 The Family Herpesviridae: General Description, Taxonomy, and Classification.- I. Description of the Family.- II. Naming of Herpesviruses.- III. Classification of Herpesviruses.- A. Grouping of Herpesviruses on the Basis of Biological Properties.- B. Grouping of Herpesviruses on the Basis of the Structure of Their Genomes.- C. Selection of Viral Properties for a Hierarchical Classification.- References.- 2 Epidemiology of Epstein—Barr Virus and Associated Diseases in Man.- I. Province of Epidemiology.- A. Epidemiology: The Study of the Distribution and of the Determinants of Diseases.- B. Epidemiological Concept of Cause.- C. Viral Diseases and Criteria for Causation.- D. Carcinogenesis: A Multistep Process.- E. Epidemiological Strategy.- II. Natural History of Epstein-Barr Virus.- A. Natural History of Epstein-Barr Virus in the Organism.- B. Natural History of Epstein-Barr Virus in Populations.- III. Disease Associated with Primary Infection by Epstein-Barr Virus: Infectious Mononucleosis.- A. Clinical, Histopathological, and Epidemiological Characterization of Infectious Mononucleosis.- B. Evidence of Causality between Epstein-Barr Virus and Infectious Mononucleosis.- C. Epstein-Barr Virus Serological Profile during Infectious Mononucleosis.- D. Deadly Lymphoid Proliferations following Epstein-Barr Virus Primary Infection.- E. Infectious Mononucleosis as a Risk Factor for Hodgkin’s Disease.- IV. Role of Epstein-Barr Virus in the Pathogenesis of Burkitt Lymphoma.- A. Clinical and Pathological Entity of Burkitt Lymphoma.- B. Geographic Distribution.- C. Age and Sex Distribution.- D. Space and Time Clustering.- E. Association between Epstein-Barr Virus and Burkitt Lymphoma.- F. Ugandan Prospective Study.- G. Epidemiological Evidence for a Causal Relationship.- H. Epstein-Barr Virus Early Infection Acts as an Initiating Event.- I. Malaria.- J. Chromosomal Anomalies.- K. Nonendemic Burkitt-Type Lymphomas and Epstein-Barr Virus.- V. Role of Epstein-Barr Virus in the Etiology and Control of Nasopharyngeal Carcinoma.- A. Pathological, Clinical, and Epidemiological Characteristics of Nasopharyngeal Carcinoma.- B. Association between Epstein-Barr Virus and Nasopharyngeal Carcinoma.- C. Epstein-Barr Virus and the Management of Nasopharyngeal Carcinoma.- D. Epstein-Barr-Virus-Related Precancerous Conditions for Nasopharyngeal Carcinoma.- E. The Future: Causality and Prevention.- VI. Summary and Conclusions.- References.- 3 Biochemistry of Epstein—Barr Virus.- I. Introduction.- II. Structural Components of the Virus.- A. Morphology of the Virus.- B. Polypeptides of the Virus.- C. Antigenic Determinants of the Virus.- D. Viral Deoxyribonucleic Acid.- III. Transformation and Latency within B Lymphocytes.- A. Viral Deoxyribonucleic Acid in Latently Infected Cells.- B. Viral Ribonucleic Acids in Latently Infected, Growth-Transformed Cells and in Burkitt-Tumor Cells in Vitro.- C. Proteins and Antigenic Reactivities in Latently Infected, Growth-Transformed Cells.- IV. Abortive and Productive Infection.- A. Viral Deoxyribonucleic Acid in Abortive and Productive Infection.- B. Viral Ribonucleic Acids in Abortive and Productive Infection.- C. Viral Proteins in Abortive and Productive Infection.- V. Summary.- References.- 4 Biology of Lymphoid Cells Transformed by Epstein—Barr Virus.- I. Establishment of Lymphoblastoid-Cell Lines from Patients.- A. Historical Background.- B. Burkitt-Lymphoma Lines.- C. Lymphoblastoid-Cell Lines from Patients with Lymphoproliferative Disease and from Normals.- D. Lymphoblastoid-Cell Lines from Patients with Infectious Mononucleosis.- II. Establishment of Lymphoblastoid-Cell Lines by in Vitro Transformation.- A. Target Cells of Epstein-Barr Virus.- B. Early Events of Transformation.- III. Surface of Epstein-Barr-Virus-Transformed Cells.- A. Lymphocyte Surface Markers.- B. Expression of HLA Antigens and ?2-Microglobulin.- C. Immune-Associated-Like Antigens.- D. Surface Antigens on Lymphoblastoid-Cell Lines Recognized by T Lymphocytes.- E. Surface Glycoproteins of Transformed Cells.- IV. Immunoglobulin Synthesis by Epstein-Barr-Virus Transformed Cells.- A. Immunoglobulin Synthesis in Burkitt-Lymphoma and Derived Cell Lines.- B. Immunoglobulin Production by Lymphoblastoid-Cell Lines.- V. Morphology and Growth Characteristics.- A. Comparison of Lymphoblastoid-Cell Lines and Burkitt-Lymphoma Lines.- B. Chromosomal Abnormalities.- C. Tumorigenicity of Epstein-Barr-Virus Transformed Cells.- VI. Epstein-Barr Viral Genome Expression in Transformed Cells.- A. Types of Cell-Virus Interactions.- B. Genome Content and Complexity.- C. Epstein-Barr Virus Antigen Expression in Transformed Cells.- References.- 5 Immunology of Epstein—Barr Virus.- I. Introduction.- II. Epstein-Barr-Virus-Specific Antigens.- A. Viral Capsid Antigen.- B. Epstein-Barr-Virus-Induced Early Antigens.- C. Epstein-Barr-Virus-Associated Nuclear Antigen.- D. Epstein-Barr-Virus-Determined Cell-Membrane Antigens.- E. Epstein-Barr-Virus-Neutralizing Antibodies.- F. Antibody-Dependent Cellular Cytotoxicity.- G. Further Antigens and Other Serological Tests.- III. Epstein-Barr-Virus-Specific Immune Responses.- A. Silent Infections.- B. Infectious Mononucleosis.- C. Primary and Persistent Epstein-Barr Virus Infections in Immunologically Compromised Individuals.- D. Epstein-Barr-Virus-Associated Malignancies.- IV. Concluding Remarks.- References.- 6 Herpesvirus saimiri and Herpesvirus ateles.- I. Introduction.- II. Natural History of Oncogenic Herpesviruses from New World Primates.- A. Herpesvirus saimiri.- B. Herpesvirus ateles.- III. Structure, Composition, and Replication of Virus Particles.- A. Permissive Cell Cultures.- B. Virion Deoxyribonucleic Acid Structures.- C. Virion Proteins.- D. Mechanism of Virus Replication.- E. Morphogenesis.- IV. Classification of Oncogenic Primate Herpesviruses.- A. Phylogenetic Relationship between Herpesvirus saimiri and Herpesvirus ateles.- B. Position of Oncogenic Herpesviruses from Nonhuman Primates within the Herpes Group.- V. Pathology of Neoplastic Diseases caused by Herpesvirus saimiri and Herpesvirus ateles.- A. Lymphomas in Marmoset Monkeys.- B. Leukemia and Lymphoma in Owl Monkeys.- C. Lymphoproliferative Diseases in Other Primates.- D. Neoplasias in Rabbits.- VI. Mechanisms of Pathogenesis in Oncogenic Transformation and Tumor Induction.- A. Permissive and Transforming Infection in Tumor-Developing Primates.- B. Immune Reactions in Neoplastic Diseases.- C. Vaccination and Chemotherapy against Tumor Disease.- D. Attenuation of Virus Strains.- E. Infectivity of Viral Deoxyribonucleic Acids in Animals.- F. Persistence and Expression of Viral Genes in Tumor Cells and Cell Lines.- G. In Vitro Transforming Potential of Herpesvirus saimiri and Herpesvirus ateles.- VII. Concluding Remarks.- References.- 7 The Molecular Biology of Marek’s Disease Herpesvirus.- I. Introduction.- II. Marek’s Disease Virus Deoxyribonucleic Acid.- A. Characterization.- B. Homology between Marek’s Disease Virus and Herpesvirus of Turkeys Deoxyribonucleic Acid.- C. Viral Genome in Transformed Cells and Tumors.- III. Proteins.- A. A and B Antigens.- B. Deoxyribonucleic Acid Polymerase.- C. Thymidine Kinase.- IV. Marek’s Disease Virus Genome Expression.- A. Transformed Cells.- B. Marek’s-Disease-Virus-Induced Tumors.- V. Comparison of Lymphoblastoid Cells Transformed by Marek’s Disease Virus with Those Transformed by Epstein-Barr Virus.- References.- 8 Biology of Marek’s Disease Virus and the Herpesvirus of Turkeys.- I. Introduction.- II. Historical Considerations.- III. Natural Occurrence.- A. Clinical Signs.- B. Host Range and Prevalence.- C. Public-Health Significance.- D. Economic Loss to the Poultry Industry.- IV. Virology.- A. Virus Morphology and Morphogenesis.- B. Physical and Chemical Properties.- C. Isolation and Cultivation.- D. Virus Strains.- E. Antigens.- F. Role of Retroviruses in Marek’s Disease.- V. Pathology.- A. Virus-Cell Relationships.- B. Gross Lesions.- C. Microscopic Lesions.- VI. Host Genetics.- A. Selection for Genetic Resistance.- B. Mode of Genetic Control.- C. Genetic Resistance and Production Traits.- VII. Immunology.- A. Immunosuppressive Effects of Marek’s Disease Virus and Herpesvirus of Turkeys Infection.- B. Immune Responses to Viral Antigens.- C. Immune Responses to Marek’s Disease Tumor-Associated Surface Antigen and Other Tumor-Associated Antigens.- D. Vaccination.- E. Nonspecific Immunostimulation.- F. Mechanisms of Resistance.- VIII. Epizootiology.- A. Spread of Infection.- B. Development of Flock Infection.- C. Factors That Affect Epizootiology.- IX. Control of Marek’s Disease.- X. Concluding Remarks.- References.



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