The Handbook of Biomarkers

ISBN-13: 9781607616849 / Angielski / Twarda / 2010 / 492 str.

Kewal K. Jain

Opis

Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain's Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Recenzje

ook fulfills the need for a single, comprehensive guide through the discovery, validation, and application of various biomarkers." (Rachel Renee Chennault, Doody's Review Service, July, 2010)

Spis treści

1. Introduction -Definitions -Historical aspects of biomarkers -Classification of biomarkers -Types of biomarkers -The ideal biomarker -Biomarkers and systems biology -Relation of biomarkers to other technologies and healthcare 2. Technologies for Discovery of Biomarkers -Introduction -Detection of biomarkers in tissues and body fluids -Disease biomarkers in breath -Genomic technologies -Epigenomic technologies -Proteomic technologies -Glycomic technologies -Metabolomic technologies -Lipidomics -Fluorescent indicators for biomarkers -Molecular imaging technologies -Nuclear magnetic resonance -Nanobiotechnology -Bioinformatics -Pitfalls in the discovery and development of biomarkers 3. Biomarkers and Molecular Diagnostics -Introduction -Molecular diagnostic technologies -Detection and expression profiling of miRNA 4. Biomarkers for Drug Discovery & Development -Introduction -Biomarker technologies for drug discovery -Biomarkers and drug safety -Applications of biomarkers for drug development 5. Role of Biomarkers in Healthcare -Introduction -Biomarkers of inflammation -Biomarkers of oxidative stress -Biomarkers in metabolic disorders -Biomarkers in immune disorders -Biomarkers of musculoskeletal disorders -Biomarkers of osteoporosis -Biomarkers of infectious diseases -Biomarkers of liver disease -Biomarkers of pancreatitis -Biomarkers of renal disease -Biomarkers of pulmonary diseases -Biomarkers in obstetrics and gynecology -Biomarkers for genetic disorders -Biomarkers of aging -Biomarkers of miscellaneous disorders -Biomarkers and nutrition -Biomarkers of gene-environmental interactions in human disease -Future role of biomarkers in healthcare -Applications of biomarkers beyond healthcare 6. Biomarkers of Cancer -Introduction -Types of cancer biomarkers -Molecular diagnostic techniques for cancer -Technologies for detection of cancer biomarkers -Applications of cancer biomarkers -Role of biomarkers in drug development in oncology -Biomarkers according to location/type of cancer -Role of the NCI in biomarkers of cancer -Future prospects for cancer biomarkers 7. Biomarkers of Disorders of the Nervous System -Introduction -Discovery of biomarkers for neurological disorders -Data mining for biomarkers of neurological disorders -Antibodies as biomarkers in disorders of the nervous system -Biomarkers of neural regeneration -Biomarkers of disruption of blood-brain barrier -Biomarkers of neurotoxicity -Biomarkers of neurodegenerative disorders -Biomarkers of multiple sclerosis -Biomarkers of stroke -Biomarkers of traumatic brain injury -Biomarkers of CNS infections -Biomarkers of epilepsy -Biomarkers of normal pressure hydrocephalus -Biomarkers of retinal disorders -Biomarkers for autism -Biomarkers of sleep disorders -Biomarkers of psychiatric disorders 8. Biomarkers of Cardiovascular Disorders -Introduction -Biomarkers of cardiovascular diseases -Methods for identification of cardiovascular biomarkers -Applications of biomarkers of cardiovascular disease -Role of biomarkers in the management of cardiovascular disease -Fut