Synthesis and Biological Activities of Organotin Schiff Base Complexes

ISBN-13: 9783659560644 / Angielski / Miękka / 2014 / 84 str.

Bukhari Iftikhar Hussain;Ahmad Imtiaz;Rehman Jeveria

Opis

2-Thiophenecarboxylic acid hydrazide has been treated with benzaldehyde in 1:1 molar ratio at room temperature in the presence of a suitable solvent to yield Schiff base. Then it has been treated with R2SnCl2/R3SnCl in 1:1 molar ratio to synthesize organotin(IV) complexes under reflux conditions. Organotin(IV) complexes have been characterized by FT-IR and semi-empirical study. FT-IR data explains the tetrahedral arrangement of sulphur donor ligand with tin metal which is further confirmed by semi-empirical study. Least value of dipole moment of complex 3 explain the trans orientation of chlorine atom around tin metal. The complexes along with ligand have also been screened for their antibacterial and antifungal activities. Organotin(IV) complexes exhibited antibectrial activities with few exceptions as compared to free ligand. Complex 4 has been found potent antibacterial agent among all complexes.

O autorze

Dr. Iftikhar Hussain Bukhari is working as a Professor and Chairman,Department of Chemistry, Government College University Faisalabad, Pakistan. He is the Life member and Associate Secretary of Chemical Society of Pakistan. He has more than 85 National and International publications. He has 26 years teaching and research experience.