Synthesis & biological investigation of fluorinated amino acid analogs

ISBN-13: 9783847348344 / Angielski / Miękka / 2012 / 100 str.

Ayse Demir

Opis

Integrins are cell surface receptors that take part in cell - cell adhesion and cell - extracellular matrix (ECM) adhesion events as well as in cell migration and cell signaling. α5β1 integrins are expressed on a wide range among brain tumor cells. In this study, an intermediate spiroisoxazolinopyrrole of the most specific α5β1 integrin antagonist SJ749 was synthesized. Fischer esterification reaction, Swern oxidation, and Wittig olefination were performed. Next, fluorinated diaminopropionate molecules were synthesized for coupling to SJ749 instead of the (2,4,6-trimethylphenyl) diaminopropionate. Finally, the biological evaluation of the molecules synthesized was performed. These assays included cytotoxicity and cell proliferation.

O autorze

Ayse Demir earned her undergraduate degree in chemistry from Fatih University, Istanbul in 2005 and M.S. Degree in 2010. She started her Ph.D. in chemistry the same year. Ayse is highly ambitious in the biological application of synthesized materials and nanoparticles. She is also interested in the analysis of drugs for pharmaceutical uses.