Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities

ISBN-13: 9783319431550 / Angielski / Twarda / 2016 / 457 str.

Georg T. Wondrak

Opis

It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.

Spis treści

Preface.

1. The skin lipidome under environmental stress – Technological platforms, molecular pathways and  translational opportunities

2. Squalene and skin barrier function: From molecular target to biomarker of environmental exposure

3. Sunlight-induced DNA damage: molecular mechanisms and photoprotection strategies

4. Urocanic Acid and Skin Photodamage: New Light on an Old Chromophore

5. The Skin Extracellular Matrix as a Target of Environmental Exposure: Molecular Mechanisms, Prevention and Repair

6. Nitric Oxide Derivatives and Skin Environmental Exposure to light: From Molecular Pathways to Therapeutic Opportunities

7. Melanocortin 1 receptor (MC1R) as a global regulator of cutaneous UV responses: molecular interactions and opportunities for melanoma prevention

8. The Cutaneous Melanocyte as a Target of Environmental Stressors: Molecular Mechanisms and Opportunities

9. The Role of Epidermal p38 Signaling in Solar UV Radiation-induced Inflammation: Molecular Pathways and Preventive Opportunities

10. UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention

11. TLR3 and Inflammatory Skin Diseases: From Environmental Factors to Molecular Opportunities

12. Sirtuins and stress response in skin cancer, aging, and barrier function

13. Cutaneous Opioid Receptors and Stress Responses: Molecular Interactions and Opportunities for Therapeutic Intervention

14. Regulation of Cutaneous Stress Response Pathways by the Circadian Clock: From Molecular Pathways to Therapeutic Opportunities

15. Endocannabinoids and Skin Barrier Function: Molecular Pathways and Therapeutic Opportunities

16. The aryl hydrocarbon receptor (AhR) as an environmental stress sensor and regulator of skin barrier function: Molecular mechanisms and therapeutic opportunities

17. Biological cell protection by natural compounds, a second line of defense against solar radiation

18. The Cutaneous Microbiota as a Determinant of Skin Barrier Function:  Molecular Interactions and Therapeutic Opportunities

19. Sensing Environmental Factors: The Emerging Role of Receptors in Epidermal Homeostasis and Whole-Body Health

20. The Cutaneous Circadian Clock as a Determinant of Environmental Vulnerability: Molecular Pathways and Chrono-pharmacological Opportunities

21. Psychological stress as a determinant of skin barrier function: Immunological pathways and therapeutic opportunities

Index

O autorze

As an Associate Professor, Pharmacology and Toxicology, College of Pharmacy, University of Arizona and President of the American Society for Photobiology (ASP; 2016-2018), Dr. Wondrak's research examines the pathological role of oxidative and proteotoxic stress in solar photodamage and skin cancer aiming at the design of novel molecular strategies for prevention and therapeutic intervention. http://www.pharmacy.arizona.edu/directory/georg-wondrak-phd