Shock, Sepsis, and Organ Failure: Third Wiggers Bernard Conference -- Cytokine Network

ISBN-13: 9783540553397 / Angielski / Miękka / 1993 / 416 str.

Ga1/4nther Schlag; Heinz Redl; Daniel Traber

Opis

An interdisciplinary approach to examining the role of cytokines in the development of sepsis and multiple organ failure. The contributions explore all aspects of two growth factors, interleukin I and interleukin VI, as far as these molecules trigger the pathological process.

Spis treści

Cytokine Cascades in Sepsis.- Tumor Necrosis Factor as a Mediator of Sepsis.- Discussion.- A Role for Interleukin-1 in Septic Shock.- Discussion.- Interleukin-6 as a Mediator of the Systemic Inflammatory Response.- Discussion.- E-Selectin, Internalization and Release.- Discussion.- Cytokines in Hemorrhage, Trauma, and Inflammation.- Alterations in Inflammatory Cytokine Production Following Hemorrhage and Resuscitation.- Discussion.- Trauma and Cytokines.- Discussion.- Quantifying the Severity of the Human Response to Injury and Sepsis as a Guide to the Interpretation of Phatophysiologic Cytokine Effects.- Discussion.- The Role of Cytokine Networks Mediating Inflammation and Ischemia-Reperfusion Injury.- Discussion.- The Role of Cytokines and Adhesion Molecules in Lung Inflammation.- Discussion.- Cytokine Response to Thermal Injury.- Discussion.- Cytokines in Gram-Positive Bacteremia.- Mechanism and Therapy of Gram-Positive Bacteremia (Sepsis) in the Nonhuman Primate: Role of Cytokines.- Discussion.- Cytokines in Gram-Positive Bacteremia.- Discussion.- Cytokines as Therapeutic Measures.- Tumor Necrosis Factor-? and Interleukin-1 Desensitization: Clinical Utility and Possible Mechanisms.- Discussion.- Interleukin-1 and its Receptor Antagonist as Candidate Therapeutic Agents for Severe Infections.- Discussion.- Cytokines in Gram-Negative Bacteremia.- The Role of TNF in Gram-Negative Sepsis in Baboon.- Discussion.- Cytokines in Overwhelming Gram-Negative Bacteremia.- Discussion.