Senescence and Mitochondria Targeted Senotherapeutics: Volume 136

ISBN-13: 9780443188862 / Angielski

Ufuk Cakatay; Mehmet Can Atayik

Opis

Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.

Spis treści

1. Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions

Jemima Princilly, Bhavana Veerabhadrappa, Nagashree N. Rao and Madhu Dyavaiah

2. Mitochondria in cell senescence: A Friend or Foe?

Qian Chen, Lindon Young, Robert Barsotti

3. The role of mitochondria and mitophagy in cell senescence

Tayyab Ali, Fatma Hussain, Haroon Ur Rashid Kayani, Muhammad Naeem, and Fozia Anjum

4. Mitochondria-associated cellular senescence mechanisms: Biochemical and pharmacological perspectives

Mehmet Can Atayik and Ufuk Çakatay

5. Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeutics

Oleh Lushchak, Dmytro Gospodaryov, Olha Strilbytska, and Maria Bayliak

6. Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases

Siarhei A. Dabravolski

7. Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction

Jan O. Nehlin

8. Melatonin as mitochondria-targeted drug

Sibel Suzen, Luciano Saso

9. Coenzyme Q-related compounds to maintain healthy mitochondria during aging

Guillermo López-Lluch

10. Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration

Komal Sharma, Joyobrata Sarkar, Anchal Trisal, Rishika Ghosh, Anubhuti Dixit, Abhishek Kumar Singh

11. Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics

Jan Homolak

12. Therapeutic targeting of mitochondria-proteostasis axis by antioxidant polysaccharides in neurodegeneration

Qiangqiang Wang, Muhammad Zeeshan Adil, Xiaoliang Xie, Shihao Zhao, Ju Zhang, and Zebo Huang

13. Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders

Priyanka Sarkar, Ashish Kumar, Partha Sarathi Behera, and Kavitha Thirumurugan