Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

ISBN-13: 9781402067280 / Angielski / Twarda / 2008 / 250 str.

Opis

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects:

• Control of tumor cell motility
• Role of tumor-cell adhesion and migration in organ-selective metastasis-formation
• Tumor heterogeneity in relation to invasion and metastasis and its clinical implications
• Tumor angiogenesis, angioprevention, anti-angiogenic therapies and response
• Role of apoptosis in the development, progression and therapy of cancer
• Role of macrophages in tumor development and metastasis
• Pathways of macrophage-mediated tumor progression
• Abnormal variation of immune response against cancer
• Immunological aspects of Marek s disease virus (MDV)-induced lymphoma progression
• A biodynamical model of human T-cell proliferative disorders
• Current methodologies for characterization of tumor directed immune response

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Spis treści

Chapter 1: Metastasis: A Current Perspective David T. Denhardt, Ann F. Chambers, Danny R. Welch Chapter 2: Control of Cell Motility during Tissue Invasion James Varani Chapter 3: Cell adhesion and invasion during secondary tumor formation Peter Gassmann, Jörg Haier and Garth L. Nicolson Chapter 4: Genes and Metastasis Alison L. Allan and Ann F. Chambers Chapter 5: The evolution of diversity within tumors and metastases Rakesh K. Singh and James E. Talmadge Chapter 6: Tumor angiogenesis, antiangiogenic therapy and anti-antiangiogenesis response Mengfeng Li Chapter 7: Apoptosis and Cancer László Kopper, István Peták Chapter 8: Macrophages in Tumour Development and Metastasis Alexandra Eichten, Karin E. de Visser, Lisa M. Coussens Chapter 9: Classical and alternative activation of macrophages: different pathways of macrophage-mediated tumor promotion Jo Van Ginderachter, Yuanqing Liu, Nick Devoogdt, Wim Noël, Lea Brys, Gholamreza Hassanzadeh Gh., Geert Raes, Anja Geldhof, Alain Beschin, Hilde Revets and Patrick De Baetselier Chapter 10: Characterization of tumor-directed cellular immune responses in humans Dirk Nagorsen, Vladia Monsurro and Francesco M. Marincola Chapter 11: Abnormal variation of the immune response as related to cancer Gerhard R.F. Krueger and Maximilian Buja Chapter 12: Immunological Aspects of Marek’s Disease Virus (MDV)-induced Lymphoma Progression Mark S. Parcells and Shane C. Burgess Chapter 13: A Biodynamical Model of Human T-Cell Development and Pathology: Design, Testing and Validation Michael E. Brandt, Gerhard R. F. Krueger and Guanyu Wang