Keynote.- On the Effectiveness of SBSE Techniques: Through Instance Space Analysis.- Research Papers.-Generating Failing Test Suites for Quantum Programs with Search.- Preliminary Evaluation of SWAY in Permutation Decision Space via a Novel Euclidean Embedding.- Search-Based Selection and Prioritization of Test Scenarios for Autonomous Driving Systems.- Search-based Automated Play Testing of Computer Games: a model-based approach.- Hybrid Multi-level Crossover for Unit Test Case Generation.- Multi-objective Test Case Selection Through Linkage Learning-driven Crossover.- Enhancing Resource-based Test Case Generation For RESTful APIs with SQL Handling.- New Ideas and Emerging Results.-Empirical Study of Effectiveness of EvoSuite on SBST 2020 Tool Competition Benchmark.- Improving Android App Responsiveness through Search-Based Frame Rate Reduction.- Challenge Solutions.-Searching for Multi-Fault Programs in Defects4J.- Refining Fitness Functions for Search-Based Automated Program Repair: A Case Study with ARJA and ARJA-e.