Role of Lipid Excipients in Modifying Oral and Parenteral Drug Delivery: Basic Principles and Biological Examples

ISBN-13: 9780471739524 / Angielski / Twarda / 2006 / 216 str.

Kishor M. Wasan

Opis

This comprehensive resource covers the fundamentals, formulation, and biopharmaceutical issues of lipid-based drug delivery. It presents the principles of lipid absorption and covers formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water-insoluble drugs.

Spis treści

Preface. Contributors. Chapter 1. Interaction of Drug Transporters with Excipients (K. Sandy Pang, Lichuan Liu, and Huadong Sun). Chapter 2. Formulation Issues around Lipid–Based Oral and Parenteral Delivery Systems (Seong Hoon Jeong, Jae Hyung Park and Kinam Park). Chapter 3. Lipid–Based Parenteral Drug Delivery Systems: Biological Implications (Vladimir P. Torchilin). Chapter 4. Principles in the Development of Intravenous Lipid Emulsions (Joanna Rossi and Jean–Christophe Leroux). Chapter 5. Protein adsorption patterns on parenteral lipid formulations–key factor determining the in vivo fate (Rainer H. Muller and Torsten M. Goppert). Chapter 6. Nanoparticle targeting for drug delivery across the blood brain barrier (James Egbert, Werner Geldenhuys, Fancy Thomas, Paul R. Lockman, Russell J. Mumper and David D. Allen). Chapter 7. Lipid–Coated Perfluorocarbon Nanostructures as Parenteral Therapeutic Agents (Evan C. Unger, Terry O. Matsunaga and Reena Zutshi). Index.

O autorze

KISHOR M. WASAN, PhD, is a Professor and Distinguished University Scholar at The University of British Columbia Faculty of Pharmaceutical Sciences. He is the Chairman of the AAPS Focus Group in Parenteral Lipid–Based Drug Delivery Systems. His research has earned him over $10 million in grants and funding, and he has written over 290 peer–reviewed publications and abstracts. In addition, he holds five patents and has worked as a consultant and publications reviewer. Dr. Wasan is a Fellow of the American Association of Pharmaceutical Sciences (AAPS) and a member of the Canadian Society of Pharmaceutical Sciences, American Pharmacists Association (APhA), and Pharmaceutics and Drug Delivery Awards Committee, among others.

Blurb

The principles and formulation of lipid–based drug delivery systems

With its promise for improving drug absorption, the emerging field of lipid–based drug delivery systems has attracted considerable attention from academia to industry. Filling the need for a standard text on the subject, this book assembles a group of experienced investigators and educators from the front line of pharmaceutical sciences to provide a comprehensive resource on the fundamentals, formulation, and biopharmaceutical issues of lipid–based drug delivery.

Presenting a solid grounding in the fundamental principles of lipid absorption in the intestines and vascular body systems, the text gives readers in–depth insight into the formulation issues, such as dissolution testing and stability testing, and physiological and biopharmaceutical issues, including the role of specific enzymes, the evaluation of transport systems in the body, and the mechanisms governing the transport of water–insoluble drugs.

Chapters cover:

• Interaction of drug transporters with excipients
• Formulation issues around lipid–based oral and parenteral delivery systems
• Biological implications of lipid–based parenteral drug delivery systems
• Principles in the development of intravenous lipid emulsions
• Protein adsorption patterns on parenteral lipid formulations a key factor determining the in vivo fate
• Nanoparticle targeting for drug delivery across the blood–brain barrier
• Lipid–coated perfluorocarbon nanostructures as parenteral therapeutic agents