Regulation of Ca2+-Atpases, V-Atpases and F-Atpases

ISBN-13: 9783319796772 / Angielski / Miękka / 2019 / 586 str.

Sajal Chakraborti;Naranjan S Dhalla

Opis

The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.

Spis treści

Part A.- 1 Historical Perspectives of Ca2+ ATPase.- 2 The Plasma Membrane Ca2+ATPases: Isoforms Specificity and 

Functional Versatility.- 3 PMCA2 w/a Splice Variant: A Key Regulator of Hair Cell Mechanotransduction Machinery.- 

4 PMCA-3, A Mysterious Isoform of Calcium Pump.- 5 The ATP2B Plasma Membrane Ca2+ ATPase Family: Regulation in 

Response to Changing Demands of Cellular Calcium Transport.- 6 The Plasma Membrane Ca2+-ATPase and the Na/Ca 

exchanger in β-cell Function and Diabetes.- 7 Long-range Allosteric Regulation of Pumps and Transporters: What Can 

We Learn From Mammalian NCX Antiporters?.- 8 Regulation of Ca2+/Mg2+ecto-ATPase in the Heart.- Part B.- 9 The 

Ca2+-ATPase of the Sarco/endoplasmic Reticulum(SERCA):Structure and Control.- 10 Functional and Structural 

Insights into Sarcolipin, a Regulator of the Sarco-Endoplasmic Reticulum Ca2+-ATPases.- 11 Regulation of  Sarco

(endo)plasmic Reticulum Calcium ATPase (SERCA) in Response to Exercise.- 12 Calcium Handling in Pulmonary 

Vasculature Under Oxidative Stress: Focus on SERCA.- 13 Plant Type 2B Ca2+-ATPases: The Diversity of Isoforms of 

the Model PlantArabidopsis Thaliana.- 14 Regulation of Ca2+ transport ATPase by Amino-and Carboxy Terminal 

Extensions: Mechanisms and (Patho)Physiological Implications.- Part A.- 15 Function and Regulation of Mammalian 

V-ATPase Isoforms.- 16 Eucaryotic V-type ATPase and its Super Complexes: From Structure and Function to Disease 

and Drug Targeting.- 17 Vacuolar ATPase in Physiology and Pathology: Roles in Neurobiology, Infectious Disease and 

Cancer.- 18 Vacular H+-ATPase Signaling in Cancer.- 19 V-ATPases and their Implication in Oral Cancer.- 20 The 

Vacular Proton ATPase (V-ATPase): Regulation and Therapeutic Targeting.- Part D.- 21 Thiol-related Regulation of 

the Mitochondrial F1Fo-ATPase Activity.- 22 F1Fo-ATPase Functions Under Markedly Acidic Conditions in Bacteria.- 

23 Tuning the ATPase Activity of Hsp 90.- 24 Role of ATPase in Disease Processes.- 25 Renal H+-ATPase Function, 

Regulation, and Role in Distal Renal Tubular Acidosis.- 26 Plasma Membrane ATPase: Potential Target for Antifungal 

Drug Therapy.- 27 The Yeast Ca2+-ATPases and Ca2+/H+ Exchangers of the Secretory Pathway and Their Regul

ation.- 28 

Role of P5A-type ATPase in Ion Homeostasis and Signalling: Shedding Light on obscure Pump.