Protein Lipidation: Volume 21

ISBN-13: 9780121227227 / Angielski / Twarda / 2000 / 322 str.

Fuyuhiko Tamanoi

Opis

This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.

• The enzymatic mechanisms of protein lipidation
• Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

Spis treści

Mechanism of Catalysis by Protein Farnesyltransferase
Structure of Protein Farnesyltransferase
Mutational Analyses of Protein Farnesyltransferase
Farnesyltransferase Inhibitors
Protein Geranylgeranyltransferase Type I
Biochemistry of Rab Geranylgeranyltransferase
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase
Reversible Modification of Proteins with Thioester-Linked Fatty Acids
Biology and Enzymology of Protein N-Myristoylation

O autorze

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.