Proteases in Gastrointestinal Tissues

ISBN-13: 9781402044823 / Angielski / Twarda / 2006 / 344 str.

Uwe Lendeckel; Nigel M. Hooper

Opis

This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.

Spis treści

Contributing Authors Preface Chapter 1 Protease-Activated Receptors in Gastrointestinal Function and Disease Nigel W. Bunnett and Graeme S. Cottrell Chapter 2 Matrix Metalloproteinases in Gastric Cancer Nikhil I. Khushalani and Nithya Ramnath Chapter 3 Proteases in Helicobacter pylori-Mediated Diseases Thomas Wex, Michael Zack, and Peter Malfertheiner Chapter 4 Proteases in Pancreatic Disease Avinash Sewpaul, Jeremy J. French, and Richard M. Charnley Chapter 5 PAR in the Pathogenesis of Pain in Pancreatic Disease Pankaj J. Pasricha Chapter 6 Importance of the Local Renin-Angiotensin System in Pancreatic Disease Po Sing Leung Chapter 7 Hepatitis C Viral Proteases And Inhibitors Mingjun Huang, Avinash Phadke and Atul Agarwal Chapter 8 Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis Yao Hong Wie Chapter 9 Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M. Sier, Bart van Hoek Chapter 10 MMPs and ADAMs in Inflammatory Bowel Disease Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko Chapter 11 Chemokines and Matrix Metalloproteinases in Colorectal Cancer Gayle G. Vaday and Stanley Zucker Chapter 12 Angiotensin-Converting Enzyme (ACE) in Gut Inflammation Fernando Magro Chapter 13 Intestinal Apical Protein Transport in Health and Disease Stephan von Hörsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona, Hassan Naim, and Marwan Alfalah Index