Part I: 1. Geriatric assessment for the older adult with cancer Arti Hurria and Harvey Jay Cohen; 2. Pharmacology and unique side-effects of chemotherapy in older adults Hans Wildier and Matti Aapro; 3. Pharmacology and unique side-effects of hormonal therapy in older adults Leona Downey; 4. Drug utilization, adherence, and unique side-effects of targeted therapy in older adults Tiffany A. Traina and Stuart M. Lichtman; 5. Principles of surgical oncology in older adults Suzanne Gaskell, Siri R. Kristjansson and Riccardo A. Audisio; 6. Principles of radiation oncology in older adults Benjamin D. Smith and Thomas A. Buccholz; Part II. Management of Solid Tumors in Older Adults: 7. Management of breast cancer in older adults Michelle Shayne and Gretchen Kimmick; 8. Management of lung cancer in older adults Suresh S. Ramalingam and Chandra P. Belani; 9. Management of head and neck cancer in older adults Julie A. Kish; 10. Management of esophagus and gastric cancer in older adults Shahzad Siddique and Jimmy Hwang; 11. Management of colon and rectal cancer in older adults Supriya Gupta Mohile, Harman P. Kaur and Richard M. Goldberg; 12. Management of renal and bladder cancer in older adults Matthew I. Milowsky and Dean F. Bajorin; 13. Management of prostate cancer in older adults Andrew Liman and Gurkamal Chatta; 14. Management of ovarian and endometrial cancer in older adults William P. Tew and Vivian von Gruenigan; Part III. Management of Hematologic Malignancies in Older Adults: 15. Management of myelodysplasia in older adults Heidi D. Klepin and Bayard L. Powell; 16. Management of chronic leukemia in older adults Martha Wadleigh and Richard Maury Stone; 17. Management of acute myeloid leukemia in older adults Arati V. Rao and Joseph O. Moore; 18. Hematopoietic cell transplantation in older adults Andrew S. Artz and William B. Ershler; 19. Management of non-Hodgkin's lymphoma in older adults Anne H. Blaes and Vicki A. Morrison; 20. Management of myeloma in older adults Amrita Y. Krishnan; Part IV. Symptom Management and Supportive Care of Older Adults: 21. Optimizing quality of life in older adults with cancer Alice B. Kornblith and Mark T. Hegel; 22. Optimizing functional status in older adults with cancer Gijsberta van Londen and Stephanie Studenski; 23. The myeloid growth factors in older adults with cancer Gary H. Lyman; 24. Erythropoiesis-stimulating agents in older adults with cancer Matthew S. McKinney and Jeffrey Crawford; 25. Management of depression and anxiety in older adults with cancer Mark I. Weinberger, Christian J. Nelson and Andrew J. Roth; 26. Management of pain in older adults with cancer Anthony Nicholas Galanos, Katya Elbert-Avila and Leslie J. Bryan; 27. Management of fatigue in older adults with cancer Betty Ferrell and Tami Borneman; 28. Management of dyspnea in older adults with cancer Amy P. Abernethy, Jane L. Wheeler and David C. Currow; 29. Management of the gastrointestinal side-effects of therapy in older adults with cancer Laura Raftery, Stephen A. Bernard and Richard M. Goldberg.