Pharmacokinetics in Drug Discovery and Development

ISBN-13: 9781566769730 / Angielski / Twarda / 2002 / 440 str.

Ronald D. Schoenwald; Schoenwald D. Schoenwald; Ronald D. Schoenwald

Opis

Detailed descriptions of the pertinent subspecialties of pharmacokinetics Chapters written by experts provide extensive background into each subspecialty Useful pharmacokinetic applications to industrial, regulatory, clinical, and research disciplines Comprehensive coverage of pharmacokinetic concepts including terminology and approaches Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference. After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.

Recenzje

"well written, making many of the approaches understandable even if, like me, the reader is not mathematically gifted. Certainly, this section has stimulated my desire to learn more, and like the Clinical Application section, I will be referring to it regularly"
- Peter Lawrence, AstraZeneca, UK, BTS Newsletter, Spring 2003

"The authors intend to provide a basic understanding and overview of numerous areas within pharmacokinetics...For anyone with a solid initial training in the field, however, this book should function quite well as a refresher on familiar areas and, more to the intended point, as an introduction to subspecialty areas."
-Gregory Reed, PhD, University of Kansas Medical Center

Spis treści

BASIC PRINCIPLES
Basic Principles
INDUSTRIAL AND REGULATORY APPLICATIONS
PK/PD Approach
Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development
Phase I, II, and III FDA Submissions
Bioavailability and Bioequivalence
CLINICAL APPLICATIONS
General Approaches to Clinical Pharmacokinetic Monitoring
Aminoglycosides and Other Antibiotics
Cardiovascular Agents
Psychotropic Agents
Theophylline
Anticonvulsant Agents
RESEARCH APPLICATIONS
Classical Modeling
Noncompartmental Modeling, An Overview
Physiologically-Based Pharmacokinetic Models
Population Pharmacokinetics
The Linear Systems Approach

O autorze

Ronald D. Schoenwald