Pharmacokinetics and Toxicokinetics

ISBN-13: 9781482221343 / Angielski / Twarda / 2015 / 550 str.

Mehdi Boroujerdi

Opis

The book unifies important topics relevant to both fields through a logical and systematic approach. It is intended to provide the principles of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It discusses the systematic overlapping of pharmacokinetics and toxicokinetics principles as well as the mathematics of modeling and interconnectivity between both topics. The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advance courses and seminars.

Spis treści

The Influence of Routes of Administration on ADME. Mechanisms of Absorption and Permeation of Xenobiotics. In Vivo Distribution of Xenobiotics. Elimination Rate, Clearance and the Theoretical Models. Renal Excretion of Xenobiotics and Estimation of Related PK/TK Parameters and Constants. Biotransformation of Xenobiotics. Kinetics of In Vitro Metabolism Assimilation of Intrinsic Clearance in Hepatic Clearance. Pharmaceutical, Biopharmaceutical, and Physiological Factors Influencing Oral Absorption of Xenobiotics-Mechanistic Absorption Models. Mathematical Modeling in Pharmacokinetics and Toxicokinetics.PK/TK Analysis of Instantaneous Exposure to Xenobiotics (Single Bolus Injection). PK/TK Analysis of Continuous Zero-Order Exposure to Xenobiotics (Intravenous Infusion). PK/TK Analysis of Xenobiotics Absorbed via an Extravascular Route of Administration (Oral Administration). PK/TK of Xenobiotics Absorbed through the Skin (Transdermal Absorption). PK/TK Analysis of Multiple Dosing. Bioavailability, Bioequivalence, and Biosimilar Evaluations. Preclinical PK/TK and Clinical Trials. Population Pharmacokinetics/Toxicokinetics. Quantitative Extrapolation Interspecies Scaling/Low Dose Extrapolation. Appendix A: Relevant Mathematical Concepts.